ArticleJournal of the American Heart Association2023
Elevated Uric Acid Is Associated With New-Onset Atrial Fibrillation: Results From the Swedish AMORIS Cohort.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- The Gut Microbiota-Metabolite-Host Axis in Cardiometabolic Diseases: Bridging Bench to Bedside.Cardiovascular drugs and therapy · 2026Review
- Gout and Risk of Ischemic Stroke in Patients With Atrial Fibrillation: A Nationwide Cohort Study.Stroke · 2026Observational
- Association of hyperuricemia with valvular heart disease and the modifying effect of obesity.The Korean journal of internal medicine · 2026Article
- Uric Acid-to-HDL Cholesterol Ratio as an Independent Predictor of In-Hospital New-Onset Atrial Fibrillation in Non-ST-Elevation Myocardial Infarction.Journal of clinical medicine · 2026Article
- Early differentiation between paroxysmal and persistent atrial fibrillation based on interpretable machine learning: a multicenter retrospective study.BioData mining · 2026Article
- Predictive factors for atrial fibrillation recurrence after radiofrequency ablation: a multifactorial approach.BMC cardiovascular disorders · 2026Article
- Beyond body mass index: visceral adiposity and metabolic alterations as early markers of atrial dysfunction and atrial fibrillation in midlife.Frontiers in endocrinology · 2026Observational
- Observational
- Discovery ofDiagnostics (Basel, Switzerland) · 2025Article
- The Impact of Hyperuricemia on the Progression of Atherosclerotic Cardiovascular Disease.Cureus · 2025Article
- Serum uric acid, renal status, cardiovascular-kidney-metabolic syndrome and drug therapy, a wide-angled Mendelian randomization analysis.American heart journal plus : cardiology research and practice · 2025Article
- Machine-learning approach to atrial fibrillation prediction among individuals without prior cardiovascular diseases.Open heart · 2025Article
- Clinical value of serum uric acid and homocysteine levels in predicting the occurrence of atrial fibrillation in patients with type 2 diabetes mellitus.Biomedical engineering online · 2025Article
- Phenotype-Based Classification of Obstructive Hypertrophic Cardiomyopathy Undergoing Myectomy.JACC. Basic to translational science · 2025Article
- Serum Urate and Atrial Fibrillation: A Bidirectional Mendelian Randomization Study.Clinical cardiology · 2025Article
- How to Prevent Arrhythmias Following Acute Coronary Syndrome.Clinical cardiology · 2025Article
- Metabolomics in Atrial Fibrillation: Unlocking Novel Biomarkers and Pathways for Diagnosis, Prognosis, and Personalized Treatment.Journal of clinical medicine · 2024Review
- Gout and Hyperuricemia: A Narrative Review of Their Comorbidities and Clinical Implications.Journal of clinical medicine · 2024Review
- Management of hypertension addressing hyperuricaemia: introduction of nano-based approaches.Annals of medicine · 2024Review
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The role of uric acid is gaining increasing importance in the evaluation of cardiovascular disease, but its relationship with atrial fibrillation (AF) is unclear. This study aims to investigate the association between uric acid levels and risk of new-onset AF. Methods and Results A total of 339 604 individuals 30 to 60 years of age and free from cardiovascular disease at baseline (1985-1996) in the Swedish AMORIS (Apolipoprotein-Mortality Risk) cohort were followed until December 31, 2019 for incident AF. Cox regression models were used to examine the association between uric acid and AF, adjusting for potential confounders and stratifying by incident cardiovascular disease. Over a mean follow-up of 25.9 years, 46 516 incident AF cases occurred. Compared with the lowest uric acid quartile, each of the upper 3 quartiles were associated with an increased risk of AF in a dose-response manner. Adjusted hazard ratios were 1.09 (95% CI, 1.06-1.12) for second quartile, 1.19 (95% CI, 1.16-1.23) for third quartile, and 1.45 (95% CI, 1.41-1.49) for fourth quartile. The association was similar among individuals with and without incident hypertension, diabetes, heart failure, or coronary heart disease. The dose-response pattern was further supported in a subsample of individuals with repeated measurements of uric acid. Conclusions Elevated uric acid was associated with an increased risk of AF, not only among people with cardiovascular disease and cardiovascular risk factors but also among those without. Future investigations are needed to examine whether lowering uric acid is relevant for AF prevention.
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