Evidence map›Paper›PMID 36632842›Full record

ArticleACS applied materials & interfaces2023

Elimination of Cancer Cells in Co-Culture: Role of Different Nanocarriers in Regulation of CD47 and Calreticulin-Induced Phagocytosis.

Eman M Hassan, Samantha McWhirter, Gilbert C Walker, Yadienka Martinez-Rubi, Shan Zou

Open access · hybridAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. The battle within: cell death by phagocytosis in cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  7. Review
  8. Nanosystem Delivers Senescence Activators and Immunomodulators to Combat Liver Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Eman M HassanMetrology Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, OntarioK1A0R6, Canada.
Samantha McWhirterDepartment of Chemistry, University of Toronto, 80 St. George St., Toronto, OntarioM5S3H6, Canada.
Gilbert C WalkerDepartment of Chemistry, University of Toronto, 80 St. George St., Toronto, OntarioM5S3H6, Canada.ORCID 0000-0002-5248-5498
Yadienka Martinez-RubiSecurity and Disruptive Technologies, National Research Council Canada, 100 Sussex Drive, Ottawa, OntarioK1A0R6, Canada.ORCID 0000-0002-1548-6504
Shan ZouMetrology Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, OntarioK1A0R6, Canada.ORCID 0000-0002-2480-6821
National Research Council Canada · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Under healthy conditions, pro- and anti-phagocytic signals are balanced. Cluster of Differentiation 47 (CD47) is believed to act as an anti-phagocytic marker that is highly expressed on multiple types of human cancer cells including acute myeloid leukemia (AML) and lung and liver carcinomas, allowing them to escape phagocytosis by macrophages. Downregulating CD47 on cancer cells discloses calreticulin (CRT) to macrophages and recovers their phagocytic activity. Herein, we postulate that using a modified graphene oxide (GO) carrier to deliver small interfering RNA (siRNA) CD47 (CD47_siRNA) in AML, A549 lung, and HepG2 liver cancer cells in co-culture

Indexed as

CD47 AntigenLeukemia, Myeloid, AcuteBoron CompoundsCalreticulinCoculture TechniquesGraphiteHumansPhagocytosisRNA, Small InterferingBoron Compoundsboron nitrideCalreticulinCD47 AntigenCD47 protein, humangraphene oxideGraphiteRNA, Small InterferingBNNTcancerCD47cytotoxicitydownregulationGOLNPsiRNA

Identifiers

PMID36632842
PMCPMC9880957
OpenAlexW4315702471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.