Evidence map›Paper›PMID 36632808›Full record

ArticleThe Analyst2023

Os(II/III) complex supports pH-insensitive electrochemical DNA-based sensing with superior operational stability than the benchmark methylene blue reporter.

Miguel Aller Pellitero, Nandini Kundu, Jonathan Sczepanski, Netzahualcóyotl Arroyo-Currás

Open access · hybridAbstract read
In one paragraph

Article in The Analyst, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Miguel Aller PelliteroDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA. netzarroyo@jhmi.edu.ORCID http://orcid.org/0000-0001-8739-2542
Nandini KunduDepartment of Chemistry, Texas A&M University, College Station, TX 77843, USA.
Jonathan SczepanskiDepartment of Chemistry, Texas A&M University, College Station, TX 77843, USA.ORCID http://orcid.org/0000-0002-9275-2597
Netzahualcóyotl Arroyo-CurrásDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA. netzarroyo@jhmi.edu.ORCID http://orcid.org/0000-0002-2740-6276
Johns Hopkins University · USTexas A&M University · US

Funding

In-Vivo Monitoring of Therapeutic Drug Transport Across Biological BarriersR01GM140143 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARROYO CURRAS, NETZAHUALCOYOTL · 2021 to 2025
$1.7M
NIGMS NIH HHS R01 GM140143
6 · The paper itself

Abstract

DNA-based electrochemical sensors use redox reporters to transduce affinity events into electrical currents. Ideally, such reporters must be electrochemically reversible, chemically stable for thousands of redox cycles, and tolerant to changing chemical environments. Here we report the first use of an Os(II/III) complex in DNA-based sensors, which undergoes pH-insensitive electron transfer with 35% better operational stability relative to the benchmark methylene blue, making it a promising reporter for continuous molecular monitoring applications where pH fluctuates with time.

Indexed as

Biosensing TechniquesMethylene BlueDNAElectrochemical TechniquesElectrodesHydrogen-Ion ConcentrationDNAMethylene Blue

Identifiers

PMID36632808
PMCPMC9924220
OpenAlexW4313561627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.