Evidence map›Paper›PMID 36632747›Full record

ReviewJournal of Zhejiang University. Science. B2023

Exosome-mediated regulatory mechanisms in skeletal muscle: a narrative review.

Zhaolu Wang, Jinjin Yang, Xiaohui Sun, Xi Sun, Gongshe Yang, Xin'e Shi

Abstract readReview
In one paragraph

Review in Journal of Zhejiang University. Science. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhaolu Wang
Jinjin YangCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Xiaohui SunCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Xi SunCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Gongshe YangCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Xin'e ShiCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China. xineshi@nwafu.edu.cn.

Funding

the National Key Research and Development Program of China 2021YFF1000602
6 · The paper itself

Abstract

Skeletal muscle plays a paramount role in physical activity, metabolism, and energy balance, while its homeostasis is being challenged by multiple unfavorable factors such as injury, aging, or obesity. Exosomes, a subset of extracellular vesicles, are now recognized as essential mediators of intercellular communication, holding great clinical potential in the treatment of skeletal muscle diseases. Herein, we outline the recent research progress in exosomal isolation, characterization, and mechanism of action, and emphatically discuss current advances in exosomes derived from multiple organs and tissues, and engineered exosomes regarding the regulation of physiological and pathological development of skeletal muscle. These remarkable advances expand our understanding of myogenesis and muscle diseases. Meanwhile, the engineered exosome, as an endogenous nanocarrier combined with advanced design methodologies of biomolecules, will help to open up innovative therapeutic perspectives for the treatment of muscle diseases.

Indexed as

ExosomesCell CommunicationHomeostasisMuscle, SkeletalExosomeInsulin resistanceMuscle atrophySkeletal muscle

Identifiers

PMID36632747
PMCPMC9837378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.