ArticlePlant biotechnology journal2023
GhWRKY41 forms a positive feedback regulation loop and increases cotton defence response against Verticillium dahliae by regulating phenylpropanoid metabolism.
Article in Plant biotechnology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- AcWRKY75 and AcMYB108 mediated ABA-GA antagonism in the regulation of pineapple internal browning.Molecular horticulture · 2026Article
- Transcriptomic and Metabolomic Analyses Reveal the Phenylpropanoid Metabolism Regulatory Network inLife (Basel, Switzerland) · 2026Article
- The Mitogen-Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis-Immunity Trade-Off in Cotton by Regulating Salicylic Acid Biosynthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Plant Flavonoids: Biosynthesis, Regulation, and Roles in Biotic and Abiotic Stresses.Plant, cell & environment · 2026Review
- Article
- Ectopic Expression of ScALDH21 From a Desert Moss Enhances Cotton Resistance to Verticillium Wilt via the Modulation of Jasmonates and Phenylpropanoid Pathways.Plant biotechnology journal · 2026Article
- Positive regulatory role of EuWRKY1 in the biosynthesis of Eucommia ulmoides rubber.Functional & integrative genomics · 2026Article
- Functional divergence of BnaWRKY7 homologs drives phytosterol variations in polyploid Brassica napus.Journal of advanced research · 2026Article
- AhNPR4B Interacts with AhPR2-Like and May Contribute to Disease Resistance and Cold Tolerance in Peanut.Plants (Basel, Switzerland) · 2026Article
- WRKY Transcription Factors: Integral Regulators of Defence Responses to Biotic Stress in Crops.Plant biotechnology journal · 2026Review
- Leucine-Rich Repeat Extension 7 Gene Confers Cotton Resistance to Verticillium Wilt.International journal of molecular sciences · 2026Article
- WRKY27-RAP2.7 Regulatory Module Promotes Cold Tolerance via Modulation of Lignin Biosynthesis and Redox Homeostasis by Regulating Cinnamyl Alcohol Dehydrogenase 7 and Glutathione S-Transferase F6.Plant biotechnology journal · 2026Article
- GbWAKL20 Phosphorylates GbNFYB8 to Modulate Verticillium Wilt Resistance in Cotton.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- GbWRKY11 Enhances Verticillium Wilt Resistance Through Activating Jasmonic Acid Biosynthesis in Cotton.Molecular plant pathology · 2026Article
- Blue light as an eco-elicitor effectively enhances flavonoid biosynthesis and antioxidant capacity in dandelion revealed by integrated metabolomic and transcriptomic analyses.BMC plant biology · 2026Article
- Enhanced resistance toFrontiers in plant science · 2026Article
- Comparative transcriptome profiling reveals a role of 24-epibrassinolide in flavonoid biosynthesis in Gleditsia sinensis.BMC plant biology · 2025Article
- Integrated chloroplast genomics and whole-genome resequencing reveals demographic history and selection signatures of black walnuts.The plant genome · 2025Article
- Regulation of important natural products biosynthesis by WRKY transcription factors in plants.Journal of advanced research · 2025Review
- WRKYs as regulatory hubs of secondary metabolic networks: Diverse inducers and distinct responses.Plant communications · 2025Review
Corrections and comments
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Authors and funding
15 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Despite the established significance of WRKY proteins and phenylpropanoid metabolism in plant immunity, how WRKY proteins modulate aspects of the phenylpropanoid pathway remains undetermined. To understand better the role of WRKY proteins in plant defence, we identified a cotton (Gossypium hirsutum) protein, GhWRKY41, that is, universally and rapidly induced in three disease-resistant cotton cultivars following inoculation with the plant pathogenic fungus, Verticillium dahliae. We show that overexpression of GhWRKY41 in transgenic cotton and Arabidopsis enhances resistance to V. dahliae, while knock-down increases cotton more susceptibility to the fungus. GhWRKY41 physically interacts with itself and directly activates its own transcription. A genome-wide chromatin immunoprecipitation and high-throughput sequencing (ChIP-seq), in combination with RNA sequencing (RNA-seq) analyses, revealed that 43.1% of GhWRKY41-binding genes were up-regulated in cotton upon inoculation with V. dahliae, including several phenylpropanoid metabolism master switches, receptor kinases, and disease resistance-related proteins. We also show that GhWRKY41 homodimer directly activates the expression of GhC4H and Gh4CL, thereby modulating the accumulation of lignin and flavonoids. This finding expands our understanding of WRKY-WRKY protein interactions and provides important insights into the regulation of the phenylpropanoid pathway in plant immune responses by a WRKY protein.
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