Evidence map›Paper›PMID 36632507›Full record

ArticleBioactive materials2023

Copper-cysteamine nanoparticle-mediated microwave dynamic therapy improves cancer treatment with induction of ferroptosis.

Hui Zhou, Zhongtao Liu, Zijian Zhang, Nil Kanatha Pandey, Eric Amador, William Nguyen, Lalit Chudal, Li Xiong, Wei Chen, Yu Wen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Pooled it
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  11. AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple-Negative Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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  13. Phototherapy in cancer treatment: strategies and challenges.Signal transduction and targeted therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Hui ZhouDepartment of General Surgery, Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Zhongtao LiuDepartment of General Surgery, Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Zijian ZhangDepartment of General Surgery, Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Nil Kanatha PandeyDepartment of Physics, The University of Texas at Arlington, Arlington, TX, 76019-0059, USA.
Eric AmadorDepartment of Physics, The University of Texas at Arlington, Arlington, TX, 76019-0059, USA.
William NguyenDepartment of Physics, The University of Texas at Arlington, Arlington, TX, 76019-0059, USA.
Lalit ChudalDepartment of Physics, The University of Texas at Arlington, Arlington, TX, 76019-0059, USA.
Li XiongDepartment of General Surgery, Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Wei ChenDepartment of Physics, The University of Texas at Arlington, Arlington, TX, 76019-0059, USA.
Yu WenDepartment of General Surgery, Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Central South University · CNThe University of Texas at Arlington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic Therapy (PDT) holds a great promise for cancer patients, however, due to the hypoxic characteristics of most solid tumors and the limited penetration depth of light in tissues, the extensive clinical application of PDT is limited. Herein, we report microwave induced copper-cysteamine (Cu-Cy) nanoparticles-based PDT as a promising cancer treatment to overcome cancer resistance in combination with ferroptosis. The treatment efficiency of Cu-Cy-mediated microwave dynamic therapy (MWDT) tested on HCT15 colorectal cancer (CRC) cells via cell titer-blue cell viability assay and live/dead assay reveal that Cu-Cy upon MW irradiation can effectively destroy HCT15 CRC cells with average IC-50 values of 20 μg/mL. The cytotoxicity of Cu-Cy to tumor cells after MW stimulation can be alleviated by ferroptosis inhibitor. Furthermore, Cu-Cy mediated MWDT could deplete glutathione peroxide 4 (GPX4) and enhance lipid peroxides (LPO) and malondialdehyde (MDA). Our findings demonstrate that MW-activated Cu-Cy killed CRC cells by inducing ferroptosis. The superior

Indexed as

Cell deathColorectal cancerCu-CyFerroptosisMicrowavePDT

Identifiers

PMID36632507
PMCPMC9807746
OpenAlexW4313203676

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.