Evidence map›Paper›PMID 36632352›Full record

ArticleJournal of translational autoimmunity2023

Development and validation of the AF score for diagnosis of adult-onset Still's disease in fever of unknown origin.

Shuni Ying, Duo Lv, Dingxian Zhu, Sheng Li, Yuwei Ding, Chuanyin Sun, Yu Shi, Hong Fang, Jianjun Qiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational autoimmunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shuni YingDepartment of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Duo LvDepartment of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Dingxian ZhuDepartment of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Sheng LiDepartment of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yuwei DingDepartment of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Chuanyin SunDepartment of Rheumatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yu ShiDepartment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hong FangDepartment of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jianjun QiaoDepartment of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
First Affiliated Hospital Zhejiang University · CNShaoxing People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To develop and validate a diagnostic score to identify adult-onset Still's disease (AOSD) in fever of unknown origin (FUO). Methods: A single center, retrospective case-control study of inpatients with FUO from January 2018 to December 2021. Using clinical and laboratory data from 178 cases with AOSD and 486 cases with FUO, we developed an AOSD/FUO (AF) score with a Bayesian Model Averaging approach. AF score and Yamaguchi's criteria were evaluated by sensitivity, specificity, accuracy, and positive/negative predictive value for diagnosis of AOSD in developmental and validation samples. Results: Persistent pruritic eruptions (PPEs) in patients with rashes was higher in AOSD group than FUO group (52.3% vs 7.4%; Conclusions: We developed and validated a new score which can identify AOSD in FUO with higher classification accuracy than Yamaguchi's criteria. Future multi-centric prospective studies need to be designed to confirm the diagnosis value of AF score.

Indexed as

Adult-onset Still's diseaseAF score, AOSD/FUO scoreAOSD, adult-onset Still's diseaseBayesian methodBMA, Bayesian Model AveragingClassification criteriaCRP, C-reactive proteinESR, erythrocyte sedimentation rateFever of unknown originFUO, fever of unknown originNPV, negative predictive valuePersistent pruritic eruptionsPIP, posterior inclusion probabilityPPEs, persistent pruritic eruptionsPPV, positive predictive value

Identifiers

PMID36632352
PMCPMC9826851
OpenAlexW4313574199

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.