Evidence map›Paper›PMID 36632340›Full record

ArticleBrain, behavior, & immunity - health2023

Intersectional vulnerability in the relationship between discrimination and inflammatory gene expression.

Adolfo G Cuevas, Colin D Freilich, Frank D Mann, Steve W Cole, Robert F Krueger

Open access · goldAbstract read
In one paragraph

Article in Brain, behavior, & immunity - health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. How community connection, homophobia, and racism shape gene expression in sexual minority men with and without HIV.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025
    Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Adolfo G CuevasDepartment of Social and Behavioral Sciences, School of Global Public Health, New York University, United States.
Colin D FreilichDepartment of Psychology, University of Minnesota, United States.
Frank D MannProgram in Public Health, Stony Brook University, United States.
Steve W ColeDepartment of Psychiatry & Biobehavioral Sciences and Medicine, University of California, Los Angeles, United States.
Robert F KruegerDepartment of Psychology, University of Minnesota, United States.
University of Minnesota · USNew York University · USStony Brook University · USUniversity of California, Los Angeles · US

Funding

U19 MIDlife in the United States-Diversity Supplement-WellsU19AG051426 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAROL D. RYFF · 2016 to 2026
$74.8M
Integrative Pathways to Cognitive, Affective, and Brain HealthU01AG077928 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sterling C Johnson, MARGIE E LACHMAN · 2022 to 2026
$17.7M
Training in genetic and neurobehavioral mechanisms of addictionT32DA050560 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Scott Ian Vrieze · 2020 to 2026
$2.0M
NIA NIH HHS U01 AG077928NIA NIH HHS U19 AG051426NIDA NIH HHS T32 DA050560
6 · The paper itself

Abstract

Addressing social disparities in health and well-being requires understanding how the effects of discrimination become biologically embedded, and how embedding processes might vary across different demographic contexts. Emerging research suggests that a threat-related gene expression response may contribute to social disparities in health. We tested a contextual vulnerability model of discrimination embedding using an empirical intersectionality (interaction discovery) analysis of pro-inflammatory gene expression in a national sample of non-institutionalized, English-speaking adults with RNA biomarker data (n = 543). At the time of data collection, the average age of participants was 55 years (SD = 13.26) and approximately half identified as female (50.46%). Most participants identified as White (∼73%) and had some college experience (∼60%). Results showed significant variation in the strength of association between daily discrimination and inflammatory gene expression by race and sex (

Indexed as

CTRADiscriminationGene expressionInflammation

Identifiers

PMID36632340
PMCPMC9826875
OpenAlexW4313400153

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.