ArticleInternational journal of pharmaceutics: X2023
3D printed matrix solid forms: Can the drug solubility and dose customisation affect their controlled release behaviour?
Article in International journal of pharmaceutics: X, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- Design of colon-targeted drug delivery of dexamethasone: Formulation and in vitro characterization of solid dispersions.Heliyon · 2024Article
- Review on Recent Advance of 3DP-Based Pediatric Drug Formulations.BioMed research international · 2024Review
- Three-dimensional (3D) printing in dental practice: Applications, areas of interest, and level of evidence.Clinical oral investigations · 2023Review
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Authors and funding
7 authors.
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Abstract
The use of 3D printing in pharmaceutics has grown over the last years, along with the number of studies on the impact of the composition of these formulations on their pharmaceutical and biopharmaceutical properties. Recently, we reported the combined effect of the infill percentage and the presence of a pore former on the drug release behaviour of 3D printed matrix solid forms prepared by fused deposition modelling. However, there are some open questions about the effect of the drug solubility and the size of these dosage forms on their controlled release properties. Therefore, we produced poly(Ɛ-caprolactone) filaments containing different soluble forms of dexamethasone (free acid, DEX; acetate ester, DEX-A; and phosphate salt, DEX-P), which showed suitable mechanical properties and printability. 3D printed solid forms were produced in two different sizes. The formulations composed of DEX-P released about 50% of drug after 10 h, while those containing DEX or DEX-A released about 9%. The drug release profiles from the 3D printed forms containing the same drug form but with different sizes were almost completely overlapped. Therefore, these 3D printed matrix solid forms can have their drug content customised by adjusting their size, without changing their controlled release behaviour.
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