Evidence map›Paper›PMID 36632065›Full record

ArticleiScience2023

Umbilical cord blood immune cell profiles in relation to the infant gut microbiome.

Yuka Moroishi, Lucas A Salas, Jie Zhou, Emily R Baker, Anne G Hoen, Todd M Everson, Carmen J Marsit, Juliette Madan, Jiang Gui, Margaret R Karagas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yuka MoroishiDepartment of Epidemiology, The Geisel School of Medicine at Dartmouth, Hanover, NH 03756, USA.
Lucas A SalasDepartment of Epidemiology, The Geisel School of Medicine at Dartmouth, Hanover, NH 03756, USA.
Jie ZhouDepartment of Epidemiology, The Geisel School of Medicine at Dartmouth, Hanover, NH 03756, USA.
Emily R BakerDepartment of Obstetrics and Gynecology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03766, USA.
Anne G HoenDepartment of Epidemiology, The Geisel School of Medicine at Dartmouth, Hanover, NH 03756, USA.
Todd M EversonGangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA 30322, USA.
Carmen J MarsitGangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA 30322, USA.
Juliette MadanDepartment of Epidemiology, The Geisel School of Medicine at Dartmouth, Hanover, NH 03756, USA.
Jiang GuiDepartment of Biomedical Data Science, The Geisel School of Medicine at Dartmouth, Hanover, NH 03756, USA.
Margaret R KaragasDepartment of Epidemiology, The Geisel School of Medicine at Dartmouth, Hanover, NH 03756, USA.
Dartmouth College · USEmory University · USDartmouth–Hitchcock Medical Center · US

Funding

VARIATION IN BIOACCUMULATION AND BIOMAGNIFICATION OF METALS IN NORTHERN US LAKESP42ES007373 · NIEHS · DARTMOUTH COLLEGE · PI STANTON, BRUCE A. · 1995 to 2019
$52.0M
Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 2013 to 2022
$23.7M
Project 3: Placental Biomarkers of Exposure and Outcome (Marsit)P01ES022832 · NIEHS · DARTMOUTH COLLEGE · PI MURRAY, CAROLYN J · 2013 to 2018
$4.7M
NIEHS NIH HHS P01 ES022832NIEHS NIH HHS P42 ES007373NIGMS NIH HHS P20 GM104416
6 · The paper itself

Abstract

During infancy, the interplay between the developing immune system and the microbiome is critical. We examined whether blood immune cell composition at birth in the umbilical cord (inferred by DNA methylation profiling) related to the early infant gut microbiome (assessed by 16S rRNA gene sequencing) among 73 infants in the New Hampshire Birth Cohort Study. We used generalized estimating equations and controlled for false discovery rate to select microbial taxa associated with immune cells. We found associations between the infant gut microbiome and immune cells, including a positive association between B cells and

Indexed as

ImmunologyMicrobiome

Identifiers

PMID36632065
PMCPMC9826880
OpenAlexW4311817900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.