ArticleThe Journal of international medical research2023
The inflammatory cytokine profiles and ocular biometric characteristics of primary angle-closure glaucoma.
Article in The Journal of international medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Multifactorial analysis of corneal biomechanical stability after deep anterior lamellar keratoplasty: integration of anterior segment imaging indices and ocular response analyzer data.American journal of translational research · 2026Article
- Changes in Choroidal Thickness and Its Effects on the Refractive Outcome After Surgical Treatment of Cataract Using Phacoemulsification Combined With Goniosynechialysis in Patients With Primary Angle Closure/Glaucoma.Journal of ophthalmology · 2025Article
- Impact of residual peripheral anterior synechiae extent on surgical outcomes after viscogonioplasty in primary angle-closure disease.International journal of ophthalmology · 2025Article
- Mendelian randomization implicates causal association between epigenetic age acceleration and age-related eye diseases or glaucoma endophenotypes.Clinical epigenetics · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the pathogenesis of primary angle-closure disease (PACG) by measuring the anatomical structures of the anterior and posterior segments of the eye and inflammatory markers in the peripheral blood.
methodsThis case-control study enrolled patients diagnosed with acute PACG (APACG) and chronic PACG (CPACG). It also enrolled control subjects without PACG. The anterior and posterior anatomical features were measured in all study participants. The levels of interleukin (IL)-6, tumour necrosis factor-α and the neutrophil-to-lymphocyte ratio (NLR) in the peripheral blood were measured.
resultsThis study analysed a total of 99 eyes: 34 eyes from 34 patients with APACG, 28 eyes from 28 patients with CPACG and 37 eyes from 37 control patients with senile cataract. The axis length, corneal diameter, anterior chamber depth and anterior chamber volume were significantly smaller in the APACG and CPACG groups compared with the controls. The level of IL-6 in the peripheral blood of patients with PACG was significantly lower than that of the controls. The NLR in the peripheral blood of patients with PACG was significantly greater than that of the controls.
conclusionsChanges in the ocular anatomy and some inflammatory markers might be involved in the pathogenesis of PACG.
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