ArticleMicrobiome2023
Expanded catalogue of metagenome-assembled genomes reveals resistome characteristics and athletic performance-associated microbes in horse.
Article in Microbiome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 46 citations in OpenAlex.
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- Dietary Supplementation of Protease and/or Amylase Improves Growth Performance, Digestive Function, and Intestinal Health of Weaned Piglets.Animals : an open access journal from MDPI · 2026Article
- A Comprehensive Review of the Equine Gut Microbiome in Health and Disease.Veterinary sciences · 2026Review
- Integrated analyses of metagenomics, metabolomics and culture-based assays reveal functional roles of gut microbiota in Felidae.NPJ biofilms and microbiomes · 2026Article
- Potential Role of Captive Environments in Reshaping the Compositions of Pathogenic Gut Bacteria inBiology · 2026Article
- A Genomic Catalog of Migratory Microbiomes from Wild Birds across China's Habitats.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Omics integration reveals how the gut microbiota of Warmblood horses responds to equestrian show jumping-a short-duration, high-intensity technical exercise stress.Animal microbiome · 2026Article
- Post-defecation exposure alters gut microbiota of forest musk deer with implications for conservation metagenomics.Applied microbiology and biotechnology · 2026Article
- Article
- Comparative metagenomic analysis of gut microbiomes in Yunnan ponies and Dutch warmblood horses.Frontiers in microbiology · 2026Article
- Multi-omics analysis reveals the potential for fermentedFrontiers in microbiology · 2026Article
- Uncovering the gut microbiome and antibiotic resistome of mammals on the Tibetan Plateau.Science China. Life sciences · 2025Article
- Symbiotic Enterococcus faecalis potentiates viral pathogenesis via fructose-1,6-bisphosphate-mediated insect gut epithelial damage.NPJ biofilms and microbiomes · 2025Article
- A unified catalog of 14,062 microbial species reference genomes provides new insight into the gut microbiota in high-altitude mammals.Microbiome · 2025Article
- Metagenomic Applications to Herbivore Gut Microbiomes: A Comprehensive Review of Microbial Diversity and Host Interactions.Animals : an open access journal from MDPI · 2025Review
- UPGG: expanding the taxonomic and functional diversity of the pig gut microbiome with an enhanced genome catalog.NPJ biofilms and microbiomes · 2025Article
- Comparative metagenomics on community structure and diversity of rhizomicrobiome associated with monoculture and soybean precedent carrot.Scientific reports · 2025Article
- Article
- The Gut Microbiome of the Asiatic Toad (Ecology and evolution · 2025Article
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Authors and funding
20 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs a domesticated species vital to humans, horses are raised worldwide as a source of mechanical energy for sports, leisure, food production, and transportation. The gut microbiota plays an important role in the health, diseases, athletic performance, and behaviour of horses.
resultsHere, using approximately 2.2 Tb of metagenomic sequencing data from gut samples from 242 horses, including 110 samples from the caecum and 132 samples from the rectum (faeces), we assembled 4142 microbial metagenome-assembled genomes (MAG), 4015 (96.93%) of which appear to correspond to new species. From long-read data, we successfully assembled 13 circular whole-chromosome bacterial genomes representing novel species. The MAG contained over 313,568 predicted carbohydrate-active enzymes (CAZy), over 59.77% of which had low similarity match in CAZy public databases. High abundance and diversity of antibiotic resistance genes (ARG) were identified in the MAG, likely showing the wide use of antibiotics in the management of horse. The abundances of at least 36 MAG (e.g. MAG belonging to Lachnospiraceae, Oscillospiraceae, and Ruminococcus) were higher in racehorses than in nonracehorses. These MAG enriched in racehorses contained every gene in a major pathway for producing acetate and butyrate by fibre fermentation, presenting potential for greater amount of short-chain fatty acids available to fuel athletic performance.
conclusionOverall, we assembled 4142 MAG from short- and long-read sequence data in the horse gut. Our dataset represents an exhaustive microbial genome catalogue for the horse gut microbiome and provides a valuable resource for discovery of performance-enhancing microbes and studies of horse gut microbiome. Video Abstract.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.