Evidence map›Paper›PMID 36631897›Full record

ArticleGenome biology2023

Sequre: a high-performance framework for secure multiparty computation enables biomedical data sharing.

Haris Smajlović, Ariya Shajii, Bonnie Berger, Hyunghoon Cho, Ibrahim Numanagić

Abstract read
In one paragraph

Article in Genome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Privacy-Enhancing Technologies in Biomedical Data Science.Annual review of biomedical data science · 2024
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haris SmajlovićDepartment of Computer Science, University of Victoria, Victoria, BC, Canada.
Ariya ShajiiCSAIL, MIT, Cambridge, MA, USA.
Bonnie BergerCSAIL, MIT, Cambridge, MA, USA. bab@mit.edu.
Hyunghoon ChoBroad Institute of MIT and Harvard, Cambridge, MA, USA. hhcho@broadinstitute.org.
Ibrahim NumanagićDepartment of Computer Science, University of Victoria, Victoria, BC, Canada. inumanag@uvic.ca.ORCID 0000-0002-2970-7937

Funding

Privacy-preserving genomic medicine at scaleR01HG010959 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BERGER, BONNIE · 2020 to 2023
$2.6M
Computational Methods for Enhancing Privacy in Biomedical Data SharingDP5OD029574 · OD · YALE UNIVERSITY · PI CHO, HYUNGHOON · 2020 to 2024
$2.0M
NHGRI NIH HHS R01 HG010959NIH HHS DP5 OD029574
6 · The paper itself

Abstract

Secure multiparty computation (MPC) is a cryptographic tool that allows computation on top of sensitive biomedical data without revealing private information to the involved entities. Here, we introduce Sequre, an easy-to-use, high-performance framework for developing performant MPC applications. Sequre offers a set of automatic compile-time optimizations that significantly improve the performance of MPC applications and incorporates the syntax of Python programming language to facilitate rapid application development. We demonstrate its usability and performance on various bioinformatics tasks showing up to 3-4 times increased speed over the existing pipelines with 7-fold reductions in codebase sizes.

Indexed as

Computational BiologyInformation DisseminationDomain-specific languageGenomic privacySecure multiparty computation

Identifiers

PMID36631897
PMCPMC9832703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.