Evidence map›Paper›PMID 36631863›Full record

ArticleBMC musculoskeletal disorders2023

The effect of interactions between BMI and sustained depressive symptoms on knee osteoarthritis over 4 years: data from the osteoarthritis initiative.

Gabby B Joseph, Charles E McCulloch, Michael C Nevitt, John Lynch, Nancy E Lane, Valentina Pedoia, Sharmila Majumdar, Thomas M Link

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabby B JosephDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA. gabby.joseph@ucsf.edu.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California, San Francisco, USA.
Michael C NevittDepartment of Epidemiology and Biostatistics, University of California, San Francisco, USA.
John LynchDepartment of Epidemiology and Biostatistics, University of California, San Francisco, USA.
Nancy E LaneDepartment of Rheumatology, University of California, Davis, USA.
Valentina PedoiaDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA.
Sharmila MajumdarDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA.
Thomas M LinkDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA.

Funding

UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 2019 to 2026
$7.1M
Understanding the mechanisms by which weight change affects progression of knee osteoarthritis in obese and overweight individuals: An analysis of the Osteoarthritis Initiative DatasetR01AR078917 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GABRIELLE JOSEPH, THOMAS M LINK · 2021 to 2026
$3.4M
The Study of Muscle, Mobility and Aging with Knee OAR01AG070647 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Nancy E Lane · 2021 to 2026
$2.5M
Impact of Weight loss on Knee Joint Biochemical and Structural DegenerationR01AR064771 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LINK, THOMAS M · 2014 to 2019
$1.6M
NIAMS NIH HHS P30 AR075055NIAMS NIH HHS R01 AR078917NIDDK NIH HHS P30 DK098722NIH HHS R01-AG070647NIH HHS R01-AR064771NIH HHS R01-AR078917
6 · The paper itself

Abstract

backgroundTo assess the compound effects of BMI and sustained depressive symptoms on changes in knee structure, cartilage composition, and knee pain over 4 years using statistical interaction analyses.

methodsOne thousand eight hundred forty-four individuals from the Osteoarthritis Initiative Database were analyzed at baseline and 4-year follow-up. Individuals were categorized according to their BMI and presence of depressive symptoms (based on the Center for Epidemiological Studies Depression Scale (threshold≥16)) at baseline and 4-year follow-up. 3 T MRI was used to quantify knee cartilage T

resultsThe BMI-depressive symptoms interaction was significantly associated with knee pain (p < 0.001) changes over 4 years, but not with changes in cartilage T

conclusionsThe compound effects of obesity and depression have greater impact on knee pain and JSN progression compared to what would be expected based on their individual effects.

Indexed as

Cartilage, ArticularOsteoarthritis, KneeBody Mass IndexDepressionDisease ProgressionFemaleHumansKnee JointMagnetic Resonance ImagingObesityPainCartilage T2DepressionJSNMRIObesity

Identifiers

PMID36631863
PMCPMC9835266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.