Evidence map›Paper›PMID 36631608›Full record

ArticleNature2023

Short tRNA anticodon stem and mutant eRF1 allow stop codon reassignment.

Ambar Kachale, Zuzana Pavlíková, Anna Nenarokova, Adriana Roithová, Ignacio M Durante, Petra Miletínová, Kristína Záhonová, Serafim Nenarokov, Jan Votýpka, Eva Horáková and 6 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
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  5. Nuclear Genome Assembly and Annotation of Kinetoplastids.Methods in molecular biology (Clifton, N.J.) · 2026
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  11. Review
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  14. Evolutionary divergent kinetoplast genome structure and RNA editing patterns in the trypanosomatidProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  19. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 4 countries.

Ambar Kachale *Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
Zuzana Pavlíková *Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic.
Anna Nenarokova *Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
Adriana RoithováInstitute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic.
Ignacio M DuranteInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
Petra MiletínováInstitute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic.
Kristína ZáhonováInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.ORCID http://orcid.org/0000-0002-5766-0267
Serafim NenarokovInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.
Jan VotýpkaInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.ORCID http://orcid.org/0000-0002-0552-9363
Eva HorákováInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic.ORCID http://orcid.org/0000-0002-3730-8979
Robert L RossThermo Fisher Scientific, Franklin, MA, USA.
Vyacheslav YurchenkoLife Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czech Republic.ORCID http://orcid.org/0000-0003-4765-3263
Petra BeznoskováInstitute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic.
Zdeněk ParisInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic. parda@paru.cas.cz.ORCID http://orcid.org/0000-0003-1019-7719
Leoš Shivaya ValášekInstitute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic. valasekl@biomed.cas.cz.ORCID http://orcid.org/0000-0001-8123-8667
Julius LukešInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic. jula@paru.cas.cz.ORCID http://orcid.org/0000-0002-0578-6618
Czech Academy of Sciences · CZUniversity of South Bohemia in České Budějovice · CZSewanee: The University of the South · USUniversity of Ostrava · CZCharles University · CZCzech Academy of Sciences, Institute of Microbiology · CZInstitute of Parasitology · CZThermo Fisher Scientific (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognate tRNAs deliver specific amino acids to translating ribosomes according to the standard genetic code, and three codons with no cognate tRNAs serve as stop codons. Some protists have reassigned all stop codons as sense codons, neglecting this fundamental principle

Indexed as

AnticodonCodon, TerminatorEukaryotic CellsGenetic CodeMutationPeptide Termination FactorsRNA, TransferCiliophoraRNA, Transfer, GluRNA, Transfer, TrpSaccharomyces cerevisiaeTrypanosoma brucei bruceiAnticodonCodon, TerminatorPeptide Termination FactorsRNA, TransferRNA, Transfer, GluRNA, Transfer, Trp

Identifiers

PMID36631608
OpenAlexW4315641880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.