Evidence map›Paper›PMID 36631569›Full record

ArticlePediatric surgery international2023

The effect of hepatocyte growth factor on intestinal adaption in an experimental model of short bowel syndrome.

George Bagias, Evangelos P Misiakos, Anestis Charalampopoulos, Nick Zavras, Stratigoula Sakellariou, Dimitrios Schizas, Igor Sukhotnik, Evangelos Giamarelos, Emmanouil Pikoulis

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Article in Pediatric surgery international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Enteric nervous system as a therapeutic target in gastrointestinal disorders.World journal of gastrointestinal pharmacology and therapeutics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

George Bagias3rd Department of Surgery, Attikon University Hospital, Athens, Greece. gorgis1991@gmail.com.
Evangelos P Misiakos3rd Department of Surgery, Attikon University Hospital, Athens, Greece.
Anestis Charalampopoulos3rd Department of Surgery, Attikon University Hospital, Athens, Greece.
Nick Zavras3rd Department of Surgery, Attikon University Hospital, Athens, Greece.
Stratigoula SakellariouInstitute of Pathology, National and Kapodistrian University of Athens, Athens, Greece.
Dimitrios Schizas1st Department of Surgery, Laikon General Hospital, Athens, Greece.
Igor SukhotnikDepartment of Pediatric Surgery B, Rappaport Faculty of Medicine, Haifa, Israel.
Evangelos Giamarelos4th Department of Internal Medicine, Attikon University Hospital, Athens, Greece.
Emmanouil Pikoulis3rd Department of Surgery, Attikon University Hospital, Athens, Greece.
University General Hospital Attikon · GRLaiko General Hospital of Athens · GRNational and Kapodistrian University of Athens · GRRappaport Family Institute for Research in the Medical Sciences · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNowadays, the standard therapy for patients with short bowel syndrome is parenteral nutrition (PN). Various growth factors have been tested to achieve weaning from prolonged PN administration. We evaluated the effect of hepatocyte growth factor (HGF) on structural intestinal adaptation and cell proliferation in a rat model of SBS.

methodsThirty Sprague-Dawley rats were divided into three groups; group A rats (sham) underwent bowel transection, group B rats underwent a 75% bowel resection, and group C rats underwent the same procedure but were treated postoperatively with HGF. Histopathologic parameters of intestinal adaptation were determined, while microarray and rt-PCR analyses of ileal RNA were also performed.

resultsTreatment with HGF resulted in significant increase in body weight, while the jejunal and ileal villus height and crypt depth were increased in HGF rats (36%, p < 0.05 and 27%, p < 0.05 respectively). Enterocyte proliferation was also significantly increased in HGF rats (21% p < 0.05). Microarray and quantitative rt-PCR analyses showed that the genes hgfac, rac 1, cdc42, and akt 1 were more than twofold up-regulated after HGF treatment.

conclusionHGF emerges as a growth factor that enhances intestinal adaptation. The future use of HGF may potentially reduce the requirement for PN in SBS patients.

Indexed as

Adaptation, PhysiologicalHepatocyte Growth FactorShort Bowel SyndromeAnimalsDisease Models, AnimalIntestinal MucosaIntestinesModels, TheoreticalRatsRats, Sprague-DawleyHepatocyte Growth FactorCell proliferationGene up-regulationHepatocyte growth factorIntestinal adaptationShort bowel syndrome

Identifiers

PMID36631569
OpenAlexW4315641963

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.