Evidence map›Paper›PMID 36631547›Full record

ArticleArchives of virology2023

Current status and molecular epidemiology of rabies virus from different hosts and regions in Malawi.

Henson Kainga, Elisha Chatanga, Marvin Collen Phonera, John Pilate Kothowa, Precious Dzimbiri, Gladson Kamwendo, Malala Mulavu, Cynthia Sipho Khumalo, Katendi Changula, Herman Chambaro and 17 more

Open access · hybridAbstract read
In one paragraph

Article in Archives of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Rabies in equids in Sudan.The Onderstepoort journal of veterinary research · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 6 institutions in 6 countries.

Henson KaingaDepartment of Veterinary Epidemiology and Public Health, Faculty of Veterinary Medicine, Lilongwe University of Agriculture and Natural Resources, PO Box 219, Lilongwe, Malawi.
Elisha ChatangaDepartment of Veterinary Pathobiology, Faculty of Veterinary Medicine, Lilongwe University of Agriculture and Natural Resources, PO Box 219, Lilongwe, Malawi.
Marvin Collen PhoneraDepartment of Animal Health and Livestock Development, Ministry of Agriculture, PO Box 2096, Lilongwe, Malawi.
John Pilate KothowaDepartment of Animal Health and Livestock Development, Ministry of Agriculture, PO Box 2096, Lilongwe, Malawi.
Precious DzimbiriDepartment of Animal Health and Livestock Development, Ministry of Agriculture, PO Box 2096, Lilongwe, Malawi.
Gladson KamwendoDepartment of Animal Health and Livestock Development, Ministry of Agriculture, PO Box 2096, Lilongwe, Malawi.
Malala MulavuDepartment of Biomedical Sciences, School of Health Sciences, University of Zambia, PO Box 32379, Lusaka, Zambia.
Cynthia Sipho KhumaloDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Zambia, PO Box 32379, Lusaka, Zambia.
Katendi ChangulaDepartment of Paraclinical Studies, School of Veterinary Medicine, University of Zambia, PO Box 32379, Lusaka, Zambia.
Herman ChambaroLaboratory of Virology, Central Veterinary Research Institute (CVRI), Ministry of Livestock and Fisheries, 10101, Lusaka, Zambia.
Hayato HarimaDepartment of Disease Control, School of Veterinary Medicine, University of Zambia, PO Box 32379, Lusaka, Zambia.
Masahiro KajiharaDivision of Global Epidemiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan.
Kholiwe MkandawireDepartment of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Lilongwe University of Agriculture and Natural Resources, PO Box 219, Lilongwe, Malawi.
Patrick ChikungwaDepartment of Animal Health and Livestock Development, Ministry of Agriculture, PO Box 2096, Lilongwe, Malawi.
Julius ChuluDepartment of Animal Health and Livestock Development, Ministry of Agriculture, PO Box 2096, Lilongwe, Malawi.
Gilson NjungaDepartment of Animal Health and Livestock Development, Ministry of Agriculture, PO Box 2096, Lilongwe, Malawi.
Simbarashe ChitangaDepartment of Biomedical Sciences, School of Health Sciences, University of Zambia, PO Box 32379, Lusaka, Zambia.
Benjamin MubembaDepartment of Wildlife Sciences, School of Natural Resources, Copperbelt University, 50100, Kitwe, Zambia.
Michihito SasakiDivision of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan.
Yasuko OrbaDivision of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan.
Yongjin QiuDepartment of Disease Control, School of Veterinary Medicine, University of Zambia, PO Box 32379, Lusaka, Zambia.
Junya YamagishiDivision of Collaboration and Education, International Institute for Zoonosis Control, Hokkaido University, Sapporo, 001-0020, Japan.
Edgar SimulunduDepartment of Disease Control, School of Veterinary Medicine, University of Zambia, PO Box 32379, Lusaka, Zambia.
Ayato TakadaDepartment of Disease Control, School of Veterinary Medicine, University of Zambia, PO Box 32379, Lusaka, Zambia.
Boniface NamangalaDepartment of Paraclinical Studies, School of Veterinary Medicine, University of Zambia, PO Box 32379, Lusaka, Zambia.
Hirofumi SawaDepartment of Disease Control, School of Veterinary Medicine, University of Zambia, PO Box 32379, Lusaka, Zambia.
Walter MuleyaDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Zambia, PO Box 32379, Lusaka, Zambia. muleyawalter@gmail.com.ORCID http://orcid.org/0000-0001-8874-3965
Hokkaido University · JPUniversity of Zambia · ZMLilongwe University of Agriculture and Natural Resources · MWNorthrise University · ZMSapporo University · JPUniversity of Namibia · NA

Funding

Japan Agency for Medical Research and Development JP21wm0125008
6 · The paper itself

Abstract

Although rabies is endemic in Malawi, there have been no studies in which rabies virus was systematically investigated and characterized in multiple animal hosts in that country. In order to provide molecular epidemiological data on rabies virus in Malawi, 683 suspected rabies case reports from 2008 to 2021 were examined, and 46 (dog = 40, cow = 5, and cat = 1) viable rabies-positive brain samples archived at the Central Veterinary Laboratory (CVL), Lilongwe, Malawi, were analyzed genetically. The results showed an increase in the submission of brain samples from 2008 to 2010, with the highest number of submissions observed in 2020. Of the 683 case reports analyzed for the period under review, 38.1% (260/683) (CI: 34.44 - 41.84) were confirmed by direct fluorescent antibody test. Among the confirmed cases, 65.4% (170/260) (CI: 59.23 - 71.09) were canine rabies. Further, phylogenetic analysis revealed that sequences from different animal hosts clustered together within the Africa 1b lineage, suggesting that the strains circulating in livestock are similar to those in domestic dogs. This finding supports the hypothesis that canine rabies is spilling over to livestock and emphasizes the need for further studies to provide data for effective control of rabies in Malawi.

Indexed as

Dog DiseasesRabiesRabies virusAnimalsCattleDogsFemaleLivestockMalawiMolecular EpidemiologyPhylogeny

Identifiers

PMID36631547
PMCPMC9834359
OpenAlexW4315618876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.