Evidence map›Paper›PMID 36631513›Full record

ArticleScientific reports2023

Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10.

Caterina Ivaldo, Mario Passalacqua, Anna Lisa Furfaro, Cristina d'Abramo, Santiago Ruiz, Prodyot K Chatterjee, Christine N Metz, Mariapaola Nitti, Philippe Marambaud

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Microvascular Health as a Key Determinant of Organismal Aging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Microorganisms · 2025
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Caterina IvaldoDepartment of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, I-16132, Genova, Italy.
Mario PassalacquaDepartment of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, I-16132, Genova, Italy.
Anna Lisa FurfaroDepartment of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, I-16132, Genova, Italy.
Cristina d'AbramoLitwin-Zucker Alzheimer's Research Center, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.
Santiago RuizLitwin-Zucker Alzheimer's Research Center, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.
Prodyot K ChatterjeeInstitute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.
Christine N MetzInstitute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.
Mariapaola Nitti *Department of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, I-16132, Genova, Italy. mariapaola.nitti@unige.it.
Philippe Marambaud *Litwin-Zucker Alzheimer's Research Center, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.
Feinstein Institute for Medical Research · USNorthwell Health · USUniversity of Genoa · IT

Funding

Therapeutic Potential of ALK1 Activating Drugs in HHT ModelsR01HL139778 · NHLBI · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI PHILIPPE MARAMBAUD · 2018 to 2026
$2.8M
mTOR and VEGFR2 pathways in HHT pathogenesisR01HL150040 · NHLBI · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI MARAMBAUD, PHILIPPE · 2020 to 2023
$1.7M
NHLBI NIH HHS R01 HL139778NHLBI NIH HHS R01 HL150040
6 · The paper itself

Abstract

Classical cadherins, including vascular endothelial (VE)-cadherin, are targeted by matrix metalloproteinases (MMPs) and γ-secretase during adherens junction (AJ) disassembly, a mechanism that might have relevance for endothelial cell (EC) integrity and vascular homeostasis. Here, we show that oxidative stress triggered by H

Indexed as

Amyloid Precursor Protein SecretasesProteasome Endopeptidase ComplexAdherens JunctionsBone Morphogenetic ProteinsCadherin 5CadherinsCells, CulturedEndothelial CellsHumansHydrogen PeroxideMatrix MetalloproteinasesOxidative StressAmyloid Precursor Protein SecretasesBMP10 protein, humanBone Morphogenetic ProteinsCadherin 5CadherinsHydrogen PeroxideMatrix MetalloproteinasesProteasome Endopeptidase Complex

Identifiers

PMID36631513
PMCPMC9834263
OpenAlexW4315589365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.