Evidence map›Paper›PMID 36631349›Full record

ArticleAcademic radiology2023

Deep Learning-based Automatic Diagnosis of Breast Cancer on MRI Using Mask R-CNN for Detection Followed by ResNet50 for Classification.

Yang Zhang, Yan-Lin Liu, Ke Nie, Jiejie Zhou, Zhongwei Chen, Jeon-Hor Chen, Xiao Wang, Bomi Kim, Ritesh Parajuli, Rita S Mehta and 2 more

Abstract read
In one paragraph

Article in Academic radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  15. Automatic classification of fungal-fungal interactions using deep leaning models.Computational and structural biotechnology journal · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yang ZhangDepartment of Radiological Sciences, University of California, Irvine, California; Department of Radiation Oncology, Rutgers-Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey.
Yan-Lin LiuDepartment of Radiological Sciences, University of California, Irvine, California.
Ke NieDepartment of Radiation Oncology, Rutgers-Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey.
Jiejie ZhouDepartment of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zhongwei ChenDepartment of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jeon-Hor ChenDepartment of Radiological Sciences, University of California, Irvine, California; Department of Radiology, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan.
Xiao WangDepartment of Radiation Oncology, Rutgers-Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey.
Bomi KimDepartment of Radiological Sciences, University of California, Irvine, California; Department of Breast Radiology, Ilsan Hospital, Goyang, South Korea.
Ritesh ParajuliDepartment of Medicine, University of California, Irvine, United States.
Rita S MehtaDepartment of Medicine, University of California, Irvine, United States.
Meihao WangDepartment of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Min-Ying SuDepartment of Radiological Sciences, University of California, Irvine, California; Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: msu@uci.edu.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Prediction of Neoadjuvant Chemo Pathological Response Using MRI MarkersR01CA127927 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI SU, MIN-YING L. · 2008 to 2017
$5.0M
Mammographic Density and Metabolic Genotyping for Predicting Cancer PrognosisR21CA208938 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, JEON-HOR, SU, MIN-YING L. · 2017 to 2018
$370k
NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA127927NCI NIH HHS R21 CA208938
6 · The paper itself

Abstract

RATIONALE AND

objectivesDiagnosis of breast cancer on MRI requires, first, the identification of suspicious lesions; second, the characterization to give a diagnostic impression. We implemented Mask Reginal-Convolutional Neural Network (R-CNN) to detect abnormal lesions, followed by ResNet50 to estimate the malignancy probability. MATERIALS AND

methodsTwo datasets were used. The first set had 176 cases, 103 cancer, and 73 benign. The second set had 84 cases, 53 cancer, and 31 benign. For detection, the pre-contrast image and the subtraction images of left and right breasts were used as inputs, so the symmetry could be considered. The detected suspicious area was characterized by ResNet50, using three DCE parametric maps as inputs. The results obtained using slice-based analyses were combined to give a lesion-based diagnosis.

resultsIn the first dataset, 101 of 103 cancers were detected by Mask R-CNN as suspicious, and 99 of 101 were correctly classified by ResNet50 as cancer, with a sensitivity of 99/103 = 96%. 48 of 73 benign lesions and 131 normal areas were identified as suspicious. Following classification by ResNet50, only 16 benign and 16 normal areas remained as malignant. The second dataset was used for independent testing. The sensitivity was 43/53 = 81%. Of the total of 121 identified non-cancerous lesions, only 6 of 31 benign lesions and 22 normal tissues were classified as malignant.

conclusionResNet50 could eliminate approximately 80% of false positives detected by Mask R-CNN. Combining Mask R-CNN and ResNet50 has the potential to develop a fully-automatic computer-aided diagnostic system for breast cancer on MRI.

Indexed as

Breast NeoplasmsDeep LearningFemaleHumansMagnetic Resonance ImagingNeural Networks, ComputerBreast MRIComputer-Aided Diagnosis (CAD)Deep LearningMask Reginal-Convolutional Neural Network (R-CNN)ResNet50

Identifiers

PMID36631349
PMCPMC10515321

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.