Evidence map›Paper›PMID 36631270›Full record

ArticleNeurology2023

Cross-Trait Mendelian Randomization Study to Investigate Whether Migraine Is a Risk Factor for Multiple Sclerosis.

Mary K Horton, Sarah C Robinson, Xiaorong Shao, Hong Quach, Diana Quach, Vidhu Choudhary, Kalliope H Bellesis, Pete Dorin, Jin Mei, Terrence Chinn and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Mary K HortonFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco. mary.horton@berkeley.edu.ORCID 0000-0002-0854-4219
Sarah C RobinsonFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.
Xiaorong ShaoFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.
Hong QuachFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.
Diana QuachFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.
Vidhu ChoudharyFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.
Kalliope H BellesisFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.
Pete DorinFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.
Jin MeiFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.
Terrence ChinnFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.
Travis J MeyersFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.
Nandini BakshiFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.
Jacqueline F MarcusFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.
Emmanuelle WaubantFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.ORCID 0000-0001-5188-0157
Catherine A SchaeferFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.
Lisa F BarcellosFrom the Division of Epidemiology (M.K.H., S.C.R., X.S., H.Q., D.Q., L.F.B.), School of Public Health, University of California, Berkeley; Computational Biology Graduate Group (M.K.H., L.F.B.), University of California, Berkeley; Kaiser Permanente Division of Research (V.C., K.H.B., P.D., J.M., T.C., T.J.M., C.A.S., L.F.B.), Oakland, CA; The Permanente Medical Group (N.B.), Walnut Creek, CA; The Permanente Medical Group (J.F.M.), San Francisco, CA; and Departments of Pediatrics and Neurology (E.W.), University of California, San Francisco.ORCID 0000-0002-0303-3479
Kaiser Permanente · US

Funding

A Resource for Genetic Epidemiology Research in Adult Health and AgingRC2AG036607 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI RISCH, NEIL J., SCHAEFER, CATHERINE ANN · 2009 to 2010
$24.8M
Multiple Sclerosis and Alzheimer's Disease/Related Dementias: Genetic and Non-Genetic Factors in Comorbidity and RiskR01NR017431 · NINR · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARCELLOS, LISA F · 2018 to 2022
$3.3M
Novel Strategies to Identify GxE Contributions to MS PathogenesisR01ES017080 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARCELLOS, LISA F · 2011 to 2015
$3.0M
Childhood stress and multiple sclerosis: implications on risk and clinical outcomesF31NS108668 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HORTON, MARY · 2018 to 2020
$121k
NIA NIH HHS RC2 AG036607NIEHS NIH HHS R01 ES017080NINDS NIH HHS F31 NS108668NINR NIH HHS R01 NR017431
6 · The paper itself

Abstract

BACKGROUND AND

objectivesMigraine is common among people with multiple sclerosis (MS), but the reasons for this are unknown. We tested 3 hypothesized mechanisms for this observed comorbidity, including migraine is a risk factor of MS, genetic variants are shared between the conditions, and migraine is because of MS.

methodsData were from 2 sources: publicly available summary statistics from genome-wide association studies of MS (N = 115,748) and migraine (N = 375,752 and N = 361,141) and a case-control study of MS recruited from the Kaiser Permanente Northern California Health Plan (N = 1,991). For the latter participants, migraine status was ascertained using a validated electronic health record migraine probability algorithm or self-report. Using the public summary statistics, we used 2-sample Mendelian randomization to test whether a migraine genetic instrumental variable was associated with MS. We used linkage disequilibrium score regression and LOGODetect to ascertain whether MS and migraine shared genetic variants across the genome and regionally. Using the Northern California MS cohort, we used logistic regression to identify whether people with both MS and migraine had different odds of clinical characteristics (e.g., age at MS onset, Perceived Deficits Questionnaire, and depression) or MS-specific risk factors (e.g., body mass index, smoking status, and infectious mononucleosis status) compared with people with MS without migraine.

resultsWe did not find evidence supporting migraine as a causal risk factor of MS ( DISCUSSION: Our findings do not support migraine as a causal risk factor of MS. Several genetic variants, particularly in the MHC, may account for some of the overlap. It seems likely that migraine within the context of MS is because of MS. Identifying what increases the risk of migraine within MS might lead to an improved treatment and quality of life.

Indexed as

Migraine DisordersMultiple SclerosisCase-Control StudiesGenome-Wide Association StudyHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideQuality of LifeRisk Factors

Identifiers

PMID36631270
PMCPMC10065202
OpenAlexW4315605996

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.