Trial reportPsychotherapy and psychosomatics2023
Real-Time fMRI Functional Connectivity Neurofeedback Reducing Repetitive Negative Thinking in Depression: A Double-Blind, Randomized, Sham-Controlled Proof-of-Concept Trial.
Trial report in Psychotherapy and psychosomatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Enhancement of the left frontoparietal network through real-time functional magnetic resonance imaging functional connectivity-informed neurofeedback and its impact on working memory in schizophrenia: A pilot study.Psychiatry and clinical neurosciences · 2025Trial
- Whole-brain mechanism of neurofeedback therapy: predictive modeling of neurofeedback outcomes on repetitive negative thinking in depression.Translational psychiatry · 2024Trial
- Targeting the dopaminergic midbrain with precision 7-Tesla biofeedback training in depression: A proof-of-principle randomized controlled trial.Molecular psychiatry · 2026Article
- Paving the way for precision treatment of psychiatric symptoms with functional connectivity neurofeedback.Translational psychiatry · 2026Article
- Advances in the Application of Brain-Computer Interface-Based Neurofeedback Training in the Rehabilitation of Patients with Major Depressive Disorder.Neuropsychiatric disease and treatment · 2026Review
- Neurofeedback in Major Depression.Advances in experimental medicine and biology · 2026Review
- Increased insular functional connectivity during repetitive negative thinking in major depression and healthy volunteers.Psychological medicine · 2025Article
- Effectiveness of fMRI-based Neurofeedback Therapy on Depression: A Systematic Review.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Review
- Functional brain network dynamics of brooding in depression: Insights from real-time fMRI neurofeedback.Journal of affective disorders · 2025Article
- Real-time fMRI neurofeedback boosts heartbeat perception by modulating insula activation pattern during interoceptive attention.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Functional brain network dynamics of brooding in depression: insights from real-time fMRI neurofeedback.medRxiv : the preprint server for health sciences · 2024Article
- Say farewell to bland regression reporting: Three forest plot variations for visualizing linear models.PloS one · 2024Article
- Thalamo-cortical circuits associated with trait- and state-repetitive negative thinking in major depressive disorder.Journal of psychiatric research · 2023Article
- Trait repetitive negative thinking in depression is associated with functional connectivity in negative thinking state rather than resting state.Journal of affective disorders · 2023Article
- Repetitive Negative Thinking-Specific and -Nonspecific White Matter Tracts Engaged by Historical Psychosurgical Targets for Depression.Biological psychiatry · 2023Article
- Article
- Trait repetitive negative thinking in depression is associated with functional connectivity in negative thinking state rather than resting state.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionRepetitive negative thinking (RNT) is a cognitive process focusing on self-relevant and negative experiences, leading to a poor prognosis of major depressive disorder (MDD). We previously identified that connectivity between the precuneus/posterior cingulate cortex (PCC) and right temporoparietal junction (rTPJ) was positively correlated with levels of RNT.
objectiveIn this double-blind, randomized, sham-controlled, proof-of-concept trial, we employed real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) to delineate the neural processes that may be causally linked to RNT and could potentially become treatment targets for MDD.
methodsMDD-affected individuals were assigned to either active (n = 20) or sham feedback group (n = 19). RNT was measured by the Ruminative Response Scale-brooding subscale (RRS-B) before and 1 week after the intervention.
resultsIndividuals in the active but not in the sham group showed a significant reduction in the RRS-B; however, a greater reduction in the PCC-rTPJ connectivity was unrelated to a greater reduction in the RRS-B. Exploratory analyses revealed that a greater reduction in the retrosplenial cortex (RSC)-rTPJ connectivity yielded a more pronounced reduction in the RRS-B in the active but not in the sham group.
conclusionsRtfMRI-nf was effective in reducing RNT. Considering the underlying mechanism of rtfMIR-nf, the RSC and rTPJ could be part of a network (i.e., default mode network) that might collectively affect the intensity of RNT. Understanding the relationship between the functional organization of targeted neural changes and clinical metrics, such as RNT, has the potential to guide the development of mechanism-based treatment of MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.