Evidence map›Paper›PMID 36630590›Full record

ArticleThe Journal of urology2023

Associations Between Urological Chronic Pelvic Pain Syndrome Symptom Flares, Illness Impact, and Health Care Seeking Activity: Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Symptom Patterns Study.

Siobhan Sutcliffe, Craig Newcomb, Catherine S Bradley, J Quentin Clemens, Bradley Erickson, Priyanka Gupta, H Henry Lai, Bruce Naliboff, Eric Strachan, Alisa Stephens-Shields

Open access · greenAbstract read
In one paragraph

Article in The Journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Siobhan SutcliffeDivision of Public Health Sciences, Department of Surgery, Alvin J. Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri.ORCID 0000-0002-4613-8107
Craig NewcombCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Catherine S BradleyDepartment of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
J Quentin ClemensDepartment of Urology, University of Michigan, Ann Arbor, Michigan.
Bradley EricksonDepartment of Urology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Priyanka GuptaDepartment of Urology, University of Michigan, Ann Arbor, Michigan.
H Henry LaiDivision of Urologic Surgery, Department of Surgery,Washington University School of Medicine, St Louis, Missouri.
Bruce NaliboffDepartment of Medicine, Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California.
Eric StrachanDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington.
Alisa Stephens-ShieldsCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
California University of Pennsylvania · USUniversity of Iowa · USUniversity of Michigan · USWashington University in St. Louis · USUniversity of California, Los Angeles · USUniversity of Washington · US

Funding

MAPP Research NetworkU01DK082316 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LANDIS, J RICHARD · 2008 to 2018
$17.2M
Role of CNS in Modulation of Pelvic Pain SyndromeU01DK082342 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KLUMPP, DAVID J · 2008 to 2021
$10.5M
Urology Chronic Pelvic Pain Longitudinal Symptom Patterns StudyU01DK082344 · NIDDK · UNIVERSITY OF IOWA · PI KREDER, KARL J · 2008 to 2021
$9.8M
University of Michigan MAPP Research Network Discovery SiteU01DK082345 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLAUW, DANIEL J, CLEMENS, J. QUENTIN · 2008 to 2021
$9.7M
Neurobiological endophenotypes & gene-environment interactions in IC/PBS & in aU01DK082370 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUTCH, JASON J., MAYER, EMERAN A · 2008 to 2021
$9.2M
WSU Urologic Chronic Pelvic Pain Syndromes Discovery CenterU01DK082325 · NIDDK · WASHINGTON STATE UNIVERSITY · PI BOGIC, MARIJA · 2008 to 2021
$9.0M
Washington University MAPP Network Discovery SiteU01DK082315 · NIDDK · WASHINGTON UNIVERSITY · PI LAI, HING HUNG HENRY · 2008 to 2021
$9.0M
MAPP Research Network Tissue Analysis and Technology CoreU01DK082333 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LUCIA, M. SCOTT · 2008 to 2018
$6.1M
NIDDK NIH HHS U01 DK082315NIDDK NIH HHS U01 DK082316NIDDK NIH HHS U01 DK082325NIDDK NIH HHS U01 DK082333NIDDK NIH HHS U01 DK082342NIDDK NIH HHS U01 DK082344NIDDK NIH HHS U01 DK082345NIDDK NIH HHS U01 DK082370
6 · The paper itself

Abstract

purposeMost studies on interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome use typical or average levels of pelvic pain or urological symptom intensity as their outcome, as both are associated with reduced quality of life. Symptom exacerbations or "flares" have also been found to be associated with reduced quality of life, but no studies, to our knowledge, have investigated whether these associations are independent of typical pelvic pain levels and thus might be useful additional outcome measures (or stated differently, whether reducing flare frequency even without reducing mean pain intensity may be important to patients). MATERIALS AND

methodsWe used screening visit and weekly run-in period data from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Symptom Patterns Study to investigate associations between flare frequency and multiple measures of illness impact and health care seeking activity, independent of typical nonflare and overall pelvic pain levels.

resultsAmong the 613 eligible participants, greater flare frequency was associated with worse condition-specific illness impact (standardized β coefficients=0.11-0.68,

conclusionsOur findings suggest that flare frequency and possibly other flare characteristics may be worth considering as additional outcome measures in urological chronic pelvic pain syndrome research to support the development of new preventive and therapeutic flare strategies.

Indexed as

cystitisinterstitialprostatitissymptom flare up

Identifiers

PMID36630590
PMCPMC10333444
OpenAlexW4315631616

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.