ArticleScience advances2023
Strong and tough fibrous hydrogels reinforced by multiscale hierarchical structures with multimechanisms.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Tailored construction and functional applications of conductive hydrogels for bioelectronic interfaces.Discover nano · 2026Review
- Composite Hydrogel With Ultra-High Mechanical Anisotropy and Biotissue-Like Softness by Confining Electrostatic and Entropic Repulsion Between Cofacially Aligned Nanosheets.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Research Progress on Material, Preparation, Properties, and Water Purification Applications of Solar Energy-Driven Hydrogels.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Self-Assembly Ordered Layered Gels for Thermochromic Smart Windows With Excellent Electromagnetic Shielding Properties.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Layer-by-layer shear densification for multiscale hierarchical alignment in bulk hydrogels.Nature communications · 2026Article
- Mechanically adaptive crack-resistant hydrogels based on strain-induced macroscopic phase separation and hierarchical energy dissipation.Nature communications · 2026Article
- Multi-scale structural engineering enables ultra-strong and tough eutectogels.Nature communications · 2026Article
- Breaking the Toughness-Stretchability Trade-Off in Hydrogels with Dynamic Hydrogen Bonding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Freeze-Derived Microporous Biomaterials for Tissue Engineering Applications.Smart medicine · 2026Review
- Thermal-driven H-bond reconfiguration for bioinspired high-strength anisotropic supramolecular hydrogels.Materials horizons · 2026Article
- Ion-Sieving Dual-Network Hydrogel Electrolytes Couple Accelerated Ion Transport with Iodide Shuttle Suppression in Aqueous Zn-INano-micro letters · 2026Article
- A Roadmap for Extreme-Mechanics Hydrogels: From Toughening Mechanisms to Intelligent System Integration.Nano-micro letters · 2026Review
- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A self-powered hydrogel electronic skin with decoupled multimodal sensing for closed-loop human-machine interactions.Nature communications · 2026Article
- Molecular clustering unlocks high-performance hydrovoltaics across temperatures from -35 °C to 80 °C.Nature communications · 2026Article
- An Elastocaloric Polymer with Ultra-High Solid-State Cooling via Defect Engineering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Autonomous Polymer Frameworks for Sustainable Tissue-Interfaced Plastic Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Supra-biomimetic Impact-Resistant Composites via Harnessing Macro-Microscale Competition.Research (Washington, D.C.) · 2026Article
- A review on thermoresponsive PNIPAM hydrogels for regenerative medicine: from mechanical design to tissue adhesion.Regenerative biomaterials · 2026Review
- Hierarchically structuralized hydrogels with ligament-like mechanical performance.Nature communications · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tough natural materials such as nacre, bone, and silk exhibit multiscale hierarchical structures where distinct toughening mechanisms occur at each level of the hierarchy, ranging from molecular uncoiling to microscale fibrillar sliding to macroscale crack deflection. An open question is whether and how the multiscale design motifs of natural materials can be translated to the development of next-generation biomimetic hydrogels. To address this challenge, we fabricate strong and tough hydrogel with architected multiscale hierarchical structures using a freeze-casting-assisted solution substitution strategy. The underlying multiscale multimechanisms are attributed to the gel's hierarchical structures, including microscale anisotropic honeycomb-structured fiber walls and matrix, with a modulus of 8.96 and 0.73 MPa, respectively; hydrogen bond-enhanced fibers with nanocrystalline domains; and cross-linked strong polyvinyl alcohol chains with chain-connecting ionic bonds. This study establishes a blueprint of structure-performance mechanisms in tough hierarchically structured hydrogels and can inspire advanced design strategies for other promising hierarchical materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.