Evidence map›Paper›PMID 36630508›Full record

ArticleScience advances2023

DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation.

Guo-Dong Chen, Iqra Fatima, Qin Xu, Elena Rozhkova, Michael Y Fessing, Andrei N Mardaryev, Andrey A Sharov, Guo-Liang Xu, Vladimir A Botchkarev

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Isolation of Mouse Hair Matrix Keratinocytes for Multi-omics Analysis.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. 5-Hydroxymethylcytosine: Far Beyond the Intermediate of DNA Demethylation.International journal of molecular sciences · 2024
    Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Guo-Dong ChenDepartment of Dermatology, Boston University, Boston, MA, USA.ORCID 0000-0001-9399-9252
Iqra FatimaDepartment of Dermatology, Boston University, Boston, MA, USA.ORCID 0000-0003-0610-5797
Qin XuState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0002-5860-8225
Elena RozhkovaDepartment of Dermatology, Boston University, Boston, MA, USA.
Michael Y FessingCentre for Skin Sciences, School of Chemistry and Biosciences, University of Bradford, Bradford, UK.ORCID 0000-0002-3120-8707
Andrei N MardaryevCentre for Skin Sciences, School of Chemistry and Biosciences, University of Bradford, Bradford, UK.ORCID 0000-0002-7826-5506
Andrey A SharovDepartment of Dermatology, Boston University, Boston, MA, USA.ORCID 0000-0002-7240-304X
Guo-Liang XuState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0002-3240-3141
Vladimir A BotchkarevDepartment of Dermatology, Boston University, Boston, MA, USA.ORCID 0000-0002-5212-5353
Boston University · USUniversity of Bradford · GBChinese Academy of Sciences · CNShanghai Medical College of Fudan University · CN

Funding

Transposable elements in the keratinocyte genome and their regulation during skin development and epidermal differentiationR01AR078306 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOTCHKAREV, VLADIMIR A, LAU, NELSON C · 2021 to 2025
$2.7M
Chromatin architectural protein CTCF and regulation of skin development and tumorigenesisR01AR071727 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOTCHKAREV, VLADIMIR A, KOHWI-SHIGEMATSU, TERUMI · 2017 to 2021
$2.6M
DNA hydroxymethylation and Tet-enzymes in the control of the skin development and hair growthR01AR075776 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOTCHKAREV, VLADIMIR A · 2019 to 2023
$1.8M
The skin of naked mole rats as a model for scar-free wound healingR33AR078093 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOTCHKAREV, VLADIMIR A, GORBUNOVA, VERA · 2023 to 2023
$406k
NIAMS NIH HHS R01 AR071727NIAMS NIH HHS R01 AR075776NIAMS NIH HHS R01 AR078306NIAMS NIH HHS R33 AR078093
6 · The paper itself

Abstract

Execution of lineage-specific differentiation programs requires tight coordination between many regulators including Ten-eleven translocation (TET) family enzymes, catalyzing 5-methylcytosine oxidation in DNA. Here, by using

Indexed as

Cell DifferentiationDioxygenasesDNAPromoter Regions, GeneticChromatinDNA-Binding ProteinsDNA MethylationEpithelial CellsChromatinDioxygenasesDNADNA-Binding ProteinsTet2 protein, mouseTet3 protein, mouse

Identifiers

PMID36630508
PMCPMC9833667
OpenAlexW4315754216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.