Evidence map›Paper›PMID 36630507›Full record

ArticleScience advances2023

Syntaxin 1 Ser

Aparna Shekar, Samuel J Mabry, Mary H Cheng, Jenny I Aguilar, Shalin Patel, Daniele Zanella, David P Saleeby, Yanqi Zhu, Tiziana Romanazzi, Paula Ulery-Reynolds and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Transient Suppression of Dopamine Transporter Palmitoylation by Methamphetamine: Implications for Transport Regulation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  3. Article
  4. Science signaling · 2025
    Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Aparna ShekarDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-7990-6352
Samuel J MabryDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-4856-4481
Mary H ChengDepartment of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0001-5833-8221
Jenny I AguilarDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Shalin PatelDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Daniele ZanellaDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-1821-6796
David P SaleebyDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Yanqi ZhuDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-8631-0784
Tiziana RomanazziDepartment of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.ORCID 0000-0001-5185-5015
Paula Ulery-ReynoldsDepartment of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8160-7802
Ivet BaharDepartment of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0001-9959-4176
Angela M CarterDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-5766-3743
Heinrich J G MatthiesDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-3615-7571
Aurelio GalliDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-7173-9345
University of Alabama at Birmingham · USUniversity of Pittsburgh · USSouthwestern Medical Center · USUniversity of Insubria · IT

Funding

The Role of the Dopamine Transporter in Psychostimulant AbuseR01DA038058 · NIDA · VANDERBILT UNIVERSITY · PI GALLI, AURELIO, MATTHIES, HEINRICH J.G. · 2014 to 2025
$4.6M
The dopamine transporter's lipid interactions: understanding transporter functionR01DA035263 · NIDA · VANDERBILT UNIVERSITY · PI GALLI, AURELIO, MATTHIES, HEINRICH J.G. · 2014 to 2023
$3.8M
NIDA NIH HHS R01 DA035263NIDA NIH HHS R01 DA038058
6 · The paper itself

Abstract

Amphetamine (AMPH) is a psychostimulant that is commonly abused. The stimulant properties of AMPH are associated with its ability to increase dopamine (DA) neurotransmission. This increase is promoted by nonvesicular DA release mediated by reversal of DA transporter (DAT) function. Syntaxin 1 (Stx1) is a SNARE protein that is phosphorylated at Ser

Indexed as

DopamineSyntaxin 1AmphetamineAnimalsDopamine Plasma Membrane Transport ProteinsDrosophila melanogasterDrosophila ProteinsPhosphorylationAmphetamineDAT protein, DrosophilaDopamineDopamine Plasma Membrane Transport ProteinsDrosophila ProteinsSyntaxin 1

Identifiers

PMID36630507
PMCPMC9833662
OpenAlexW4315631461

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.