ArticleScience advances2023
Experience-dependent plasticity of gustatory insular cortex circuits and taste preferences.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Associations between ICU survival and self-perceived appetite, smell, and taste relative to general ward patients: A prospective study.JPEN. Journal of parenteral and enteral nutrition · 2026Observational
- Taste exposure during different developmental phases impacts aversion learning in adult rats.Behavioral neuroscience · 2026Article
- Postnatal Development of Pyramidal Neurons Excitability and Synaptic Inputs in Mouse Gustatory Cortical Circuits.eNeuro · 2026Article
- A brain stem circuit integrating reflexive and anticipatory salivation.Cell reports · 2026Article
- Changes in Palatability Processing across the Estrous Cycle Are Modulated by Hypothalamic Estradiol Signaling.eNeuro · 2026Article
- Experience-dependent maturation of somatosensory parvalbumin interneurons during social development in prairie voles.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Insular cortex predictions regulate glucose homeostasis.bioRxiv : the preprint server for biology · 2025Article
- Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Postnatal development of pyramidal neurons excitability and synaptic inputs in mouse gustatory cortical circuits.bioRxiv : the preprint server for biology · 2025Article
- The health impacts and genetic architecture of food liking in cardio-metabolic diseases.Nature communications · 2025Article
- Flavor and Well-Being: A Comprehensive Review of Food Choices, Nutrition, and Health Interactions.Food science & nutrition · 2025Review
- Taste Plasticity in Nutrition and Health: A Scoping Review.Nutrients · 2025Article
- Deficits in taste-guided behaviors and central processing of taste in the transgenic TDP-43Neurobiology of disease · 2025Article
- Modulation of sweet preference by neurosteroid-sensitive, δ-GABACurrent biology : CB · 2025Article
- Neurobehavioral plasticity in the rodent gustatory system induced by regular consumption of a low-calorie sweetener during adolescence.Scientific reports · 2025Article
- Unraveling the Pathogenesis of Post-Stroke Depression in a Hemorrhagic Mouse Model through Frontal Lobe Circuitry and JAK-STAT Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Uncovering Interoceptive Human Insular Lobe Function through Intraoperative Cortical Stimulation-A Review.Brain sciences · 2024Review
- Learning enhances representations of taste-guided decisions in the mouse gustatory insular cortex.Current biology : CB · 2024Article
- Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Early experience with food influences taste preference in adulthood. How gustatory experience influences development of taste preferences and refinement of cortical circuits has not been investigated. Here, we exposed weanling mice to an array of taste solutions and determined the effects on the preference for sweet in adulthood. We demonstrate an experience-dependent shift in sucrose preference persisting several weeks following the termination of exposure. A shift in sucrose palatability, altered neural responsiveness to sucrose, and inhibitory synaptic plasticity in the gustatory portion of the insular cortex (GC) were also induced. The modulation of sweet preference occurred within a restricted developmental window, but restoration of the capacity for inhibitory plasticity in adult GC reactivated the sensitivity of sucrose preference to taste experience. Our results establish a fundamental link between gustatory experience, sweet preference, inhibitory plasticity, and cortical circuit function and highlight the importance of early life nutrition in setting taste preferences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.