Evidence map›Paper›PMID 36630455›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Neuronal membrane proteasomes regulate neuronal circuit activity in vivo and are required for learning-induced behavioral plasticity.

Hai-Yan He, Arifa Ahsan, Reshmi Bera, Natalie McLain, Regina Faulkner, Kapil V Ramachandran, Seth S Margolis, Hollis T Cline

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 30 citations in OpenAlex.

  1. Bioorthogonal Chemistry in Neurobiology: From Imaging to Proteomics.Chembiochem : a European journal of chemical biology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. ACS chemical neuroscience · 2026
    Article
  6. Article
  7. Assessing circuit function in the developingFrontiers in behavioral neuroscience · 2026
    Review
  8. Article
  9. Review
  10. PI31 expression is neuroprotective in a mouse model of early-onset parkinsonism.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Promoting proteostasis by cAMP/PKA and cGMP/PKG.Trends in molecular medicine · 2025
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Hai-Yan HeDepartment of Biology, Georgetown University, Washington, DC 20057.ORCID 0000-0002-6692-6012
Arifa AhsanDepartment of Biology, Georgetown University, Washington, DC 20057.
Reshmi BeraDepartment of Biology, Georgetown University, Washington, DC 20057.
Natalie McLainDepartment of Neuroscience, Scripps Research Institute, La Jolla, CA 92037.ORCID 0000-0001-5502-3670
Regina FaulknerDepartment of Neuroscience, Scripps Research Institute, La Jolla, CA 92037.
Kapil V RamachandranDepartment of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032.
Seth S MargolisDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Hollis T ClineDepartment of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032.ORCID 0000-0002-4887-9603
Georgetown University · USScripps Research Institute · USColumbia University Irving Medical Center · USJohns Hopkins University · US

Funding

Activity-dependent Development of Visual System DevelopmentR01EY011261 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI CLINE, HOLLIS T. · 1996 to 2018
$11.1M
Institutional Career Development CoreKL2TR001432 · NCATS · GEORGETOWN UNIVERSITY · PI UMANS, JASON G · 2015 to 2024
$7.5M
Experience-dependent Cellular Plasticity MechanismsR01EY031597 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI CLINE, HOLLIS T. · 2021 to 2025
$3.6M
Mechanisms Regulating Neuronal Specific Proteasomes in NeurodegenerationR01NS110754 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MARGOLIS, SETH S · 2019 to 2023
$2.0M
Molecular determinants of neuronal protein homeostasis through plasma membrane-localized proteasome complexes.DP5OD028133 · OD · HARVARD UNIVERSITY · PI RAMACHANDRAN, KAPIL · 2019 to 2023
$2.0M
In vivo functional analysis of a neuronal membrane-specific proteasome complexR21NS114975 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI CLINE, HOLLIS T. · 2020 to 2020
$532k
NCATS NIH HHS KL2 TR001432NEI NIH HHS R01 EY011261NEI NIH HHS R01 EY031597NIH HHS DP5 OD028133NINDS NIH HHS R01 NS110754NINDS NIH HHS R21 NS114975
6 · The paper itself

Abstract

Protein degradation is critical for brain function through processes that remain incompletely understood. Here, we investigated the in vivo function of the 20S neuronal membrane proteasome (NMP) in the brain of

Indexed as

NeuronsProteasome Endopeptidase ComplexAnimalsAvoidance LearningLarvaNeuronal PlasticitySuperior ColliculiTectum MesencephaliXenopus laevisProteasome Endopeptidase Complexactivity-induced nascent proteinsBONCATneuronproteasomespontaneous activity

Identifiers

PMID36630455
PMCPMC9934054
OpenAlexW4315621400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.