Evidence map›Paper›PMID 36630138›Full record

ArticleJAMA network open2023

Revision of the Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis Classification Schema for Melanocytic Lesions: A Consensus Statement.

Raymond L Barnhill, David E Elder, Michael W Piepkorn, Stevan R Knezevich, Lisa M Reisch, Megan M Eguchi, Boris C Bastian, Willeke Blokx, Marcus Bosenberg, Klaus J Busam and 24 more

2 registry-linked trialsAbstract readConsensus Statement
In one paragraph

Article in JAMA network open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05004792 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Correlation Between Online Case-based Training of Pathologists in Dermoscopic Images and Diagnostic Accuracy in Histopathological Interpretation of Skin Lesions Suspicious of Melanoma

TypeinterventionalSponsorHerlev HospitalRan2026 to 2027Enrolled258ConditionsMelanoma, Pigmented LesionsArmsDermLoop Learn
NCT05712551 completednot on this map

Diagnostic Agreement Among Expert Dermatopathologists on Skin Lesions Clinically Suspicious of Melanoma

TypeobservationalSponsorHerlev HospitalRan2023 to 2024Enrolled4ConditionsMelanoma (Skin), Pigmented Lesions
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Natural language processing in dermatology: A systematic literature review and state of the art.Journal of the European Academy of Dermatology and Venereology : JEADV · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Raymond L BarnhillDepartment of Translational Research, Institut Curie, Unit of Formation and Research of Medicine University of Paris, Paris, France.
David E ElderDepartment of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia.
Michael W PiepkornDivision of Dermatology, Department of Medicine, University of Washington School of Medicine, Seattle.
Stevan R KnezevichPathology Associates, Clovis, California.
Lisa M ReischDepartment of Biostatistics, University of Washington School of Medicine, Seattle.
Megan M EguchiDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles.
Boris C BastianDepartments of Pathology and Dermatology, University of California, San Francisco.
Willeke BlokxDepartment of Pathology, Division Laboratories, Pharmacy and Biomedical Genetics University Medical Center Utrecht, Utrecht, the Netherlands.
Marcus BosenbergDepartments of Dermatology, Pathology, and Immunobiology, Yale School of Medicine, New Haven, Connecticut.
Klaus J BusamDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Richard CarrCellular Pathology, South Warwickshire NHS Trust, Warwick, United Kingdom.
Alistair CochranDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles.
Martin G CookDepartment of Histopathology, Royal Surrey NHS Foundation Trust, Guildford, United Kingdom.
Lyn M DuncanPathology Service, Massachusetts General Hospital, Harvard Medical School, Boston.
Rosalie ElenitsasDepartment of Dermatology, Hospital of the University of Pennsylvania, Philadelphia.
Arnaud de la FouchardièreDepartment of Biopathology, Centre Léon Bérard, Lyon, France.
Pedram GeramiDepartment of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Iva JohanssonDepartment of Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Jennifer KoDepartment of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio.
Gilles LandmanDepartment of Pathology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Alexander J LazarDepartments of Pathology, Dermatology, and Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston.
Lori LoweDepartments of Pathology and Dermatology, University of Michigan, Ann Arbor.
Daniela MassiSection of Pathology, Department of Health Sciences, University of Florence, Florence, Italy.
Jane MessinaDepartments of Pathology and Cutaneous Oncology, Moffitt Cancer Center, Tampa, Florida.
Daniela Mihic-ProbstDepartment of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Douglas C ParkerDepartments of Pathology and Dermatology, Emory University School of Medicine, Atlanta, Georgia.
Birgitta SchmidtDepartment of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Christopher R SheaDepartment of Dermatology, University of Chicago Medicine, Chicago, Illinois.
Richard A ScolyerCharles Perkins Centre, The University of Sydney, Sydney, Australia.
Michael TetzlaffDepartments of Pathology and Dermatology, University of California, San Francisco.
Xiaowei XuDepartment of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia.
Iwei YehDepartments of Pathology and Dermatology, University of California, San Francisco.
Artur ZembowiczTufts University, Boston, Massachusetts.
Joann G ElmoreDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles.

Funding

Molecular and immunologic evolution of melanomas from pre-neoplastic lesionsR35CA220481 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASTIAN, BORIS C. · 2017 to 2023
$6.3M
Reducing Errors in the Diagnosis of Melanoma and Melanocytic LesionsR01CA201376 · NCI · UNIVERSITY OF WASHINGTON · PI ELMORE, JOANN G, KERR, KATHLEEN F. · 2016 to 2020
$3.2M
NCI NIH HHS R01 CA201376NCI NIH HHS R35 CA220481
6 · The paper itself

Abstract

Importance: A standardized pathology classification system for melanocytic lesions is needed to aid both pathologists and clinicians in cataloging currently existing diverse terminologies and in the diagnosis and treatment of patients. The Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis (MPATH-Dx) has been developed for this purpose. Objective: To revise the MPATH-Dx version 1.0 classification tool, using feedback from dermatopathologists participating in the National Institutes of Health-funded Reducing Errors in Melanocytic Interpretations (REMI) Study and from members of the International Melanoma Pathology Study Group (IMPSG). Evidence Review: Practicing dermatopathologists recruited from 40 US states participated in the 2-year REMI study and provided feedback on the MPATH-Dx version 1.0 tool. Independently, member dermatopathologists participating in an IMPSG workshop dedicated to the MPATH-Dx schema provided additional input for refining the MPATH-Dx tool. A reference panel of 3 dermatopathologists, the original authors of the MPATH-Dx version 1.0 tool, integrated all feedback into an updated and refined MPATH-Dx version 2.0. Findings: The new MPATH-Dx version 2.0 schema simplifies the original 5-class hierarchy into 4 classes to improve diagnostic concordance and to provide more explicit guidance in the treatment of patients. This new version also has clearly defined histopathological criteria for classification of classes I and II lesions; has specific provisions for the most frequently encountered low-cumulative sun damage pathway of melanoma progression, as well as other, less common World Health Organization pathways to melanoma; provides guidance for classifying intermediate class II tumors vs melanoma; and recognizes a subset of pT1a melanomas with very low risk and possible eventual reclassification as neoplasms lacking criteria for melanoma. Conclusions and Relevance: The implementation of the newly revised MPATH-Dx version 2.0 schema into clinical practice is anticipated to provide a robust tool and adjunct for standardized diagnostic reporting of melanocytic lesions and management of patients to the benefit of both health care practitioners and patients.

Indexed as

MelanomaSkin NeoplasmsConsensusHealth FacilitiesHumansPathologists

Identifiers

PMID36630138
PMCPMC10375511

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.