Evidence map›Paper›PMID 36629999›Full record

ArticleClinical rheumatology2023

Decreased natural killer T-like cells correlated to disease activity in systemic lupus erythematosus.

Sumei Tang, Yushu Wang, Xiangbo Ma, Xiaohong Xiang, Xinhua Zhou, Yan Li, Yuan Jia, Fanlei Hu, Yingni Li

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Article in Clinical rheumatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Sumei Tang *Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), 11 Xizhimen South St, Beijing, 100044, China.
Yushu Wang *Inspection Center, Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital, Yantai, 264000, China.
Xiangbo MaDepartment of Rheumatology and Immunology, Handan First Hospital, Hebei, China.
Xiaohong XiangDepartment of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), 11 Xizhimen South St, Beijing, 100044, China.
Xinhua ZhouClinical Laboratory, Third Hospital of Nanchang, Jiangxi, 330009, China.
Yan LiClinical Laboratory, First People's Hospital of Jinzhong, Shanxi, 030600, China.
Yuan JiaDepartment of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), 11 Xizhimen South St, Beijing, 100044, China.
Fanlei HuDepartment of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), 11 Xizhimen South St, Beijing, 100044, China. fanleihu@bjmu.edu.cn.
Yingni LiDepartment of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), 11 Xizhimen South St, Beijing, 100044, China. ying8436@aliyun.com.ORCID http://orcid.org/0000-0001-5817-9400

Funding

National Natural Science Foundation of China 81871281National Natural Science Foundation of China 82171773Research and Development project of Peking University People's Hospital RDC2019-01
6 · The paper itself

Abstract

objectivesTo evaluate the absolute numbers and frequencies of natural killer T-like (NKT-like) cells in systemic lupus erythematosus (SLE) and to characterize the possible role of the cells.

methodsSeventy-nine patients with SLE together with 30 age- and sex-matched healthy controls were enrolled. Flow cytometric determination of peripheral NKT-like cells was carried out for all participants by detecting the absolute counts (Abs) and percentage (%) of CD3 + CD16 + CD56 + cells. Disease activity index, laboratory parameters, and clinical manifestations were collected. The correlation between the cells and these parameters was analyzed.

resultsSLE patients had, with respect to controls, considerably decreased values of NKT-like cells (P < 0.001 in both absolute number and percentage). The absolute number of NKT-like cells was found to have positive correlations with WBC, RBC, PLT, C3, C4, IgM and negative correlations with the disease duration, SLEDAI-2 K, anti-dsDNA, anti-nucleosome, anti-ribosomal protein, CRP, ESR. Meanwhile, it was found that the percentage values of NKT-like cells decreased in SLE patients with nephritis which was correlated with anti-ribosomal protein and CRP in comparison to SLE patients without nephritis. Moreover, an increase in the NKT-like cell counts was also observed in the patients with a clinical response to the treatment.

conclusionsThe absolute counts and frequencies of NKT-like cells decreased in SLE patients significantly, which correlated to disease activities and could recover to normal after the treatment. The NKT-like cells may play an important role in the pathogenesis of SLE and could be a useful marker in the disease assessment. Key Points • The absolute counts and frequencies of NKT-like cells decreased in SLE patients significantly. • NKT-like cells were related to the disease activities and could restore after the treatment. • NKT-like cells may be a useful marker in the disease assessment.

Indexed as

Lupus Erythematosus, SystemicNephritisFlow CytometryHumansKiller Cells, NaturalDisease activityNKT-like cellsSystemic lupus erythematosusT-lymphocytes

Identifiers

PMID36629999

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