Evidence map›Paper›PMID 36629845›Full record

ArticleThe CRISPR journal2023

Gene Editing Corrects

Delphine Leclerc, Louise Goujon, Sylvie Jaillard, Bénédicte Nouyou, Laurence Cluzeau, Léna Damaj, Christèle Dubourg, Amandine Etcheverry, Thierry Levade, Roseline Froissart and 8 more

Abstract read
In one paragraph

Article in The CRISPR journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Delphine LeclercINSERM U1242, OSS, Univ Rennes, Rennes, France.
Louise GoujonCHU Rennes, Service de Génétique Clinique, Centre de Référence Maladies Rares CLAD-Ouest, FHU GenOMEDS, ERN ITHACA, Hôpital Sud, Rennes, France.
Sylvie JaillardINSERM, EHESP, IRSET-UMR_S, 1085, Université Rennes 1, Rennes, France.
Bénédicte NouyouService de Cytogénétique et Biologie Cellulaire, CHU Rennes, Rennes, France.
Laurence CluzeauService de Cytogénétique et Biologie Cellulaire, CHU Rennes, Rennes, France.
Léna DamajDepartment of Pediatrics, Competence Center of Inherited Metabolic Disorders, Rennes Hospital, Rennes, France.
Christèle DubourgLaboratoire de Génétique Moléculaire et Génomique, Centre Hospitalier Universitaire de Rennes, Rennes, France.
Amandine EtcheverryLaboratoire de Génétique Moléculaire et Génomique, Centre Hospitalier Universitaire de Rennes, Rennes, France.
Thierry LevadeLaboratoire de Biochimie, CHU de Toulouse, Pôle biologie, Institut Fédératif de Biologie, Toulouse, France.
Roseline FroissartCHU Lyon HCL, LBMMS-Service Biochimie et Biologie Moléculaire, UM Pathologies Héréditaires du Métabolisme et du Globule Rouge, Bron, France.
Stéphane DréanoUniv Rennes, CNRS, IGDR (Institut de Génétique et Développement de Rennes), UMR 6290, ERL U1305, Rennes, France.
Xavier GuilloryINSERM U1242, OSS, Univ Rennes, Rennes, France.
Leif A ErikssonDepartment of Chemistry and Molecular Biology, University of Gothenburg, Göteborg, Sweden.ORCID 0000-0001-5654-3109
Erika LaunayService de Cytogénétique et Biologie Cellulaire, CHU Rennes, Rennes, France.
Frédéric MouriauxINSERM U1242, OSS, Univ Rennes, Rennes, France.
Marc-Antoine Belaud-RotureauINSERM, EHESP, IRSET-UMR_S, 1085, Université Rennes 1, Rennes, France.
Sylvie OdentCHU Rennes, Service de Génétique Clinique, Centre de Référence Maladies Rares CLAD-Ouest, FHU GenOMEDS, ERN ITHACA, Hôpital Sud, Rennes, France.
David GilotINSERM U1242, OSS, Univ Rennes, Rennes, France.ORCID 0000-0002-2646-671X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ganglioside-monosialic acid (GM1) gangliosidosis, a rare autosomal recessive disorder, is frequently caused by deleterious single nucleotide variants (SNVs) in

Indexed as

Gangliosidosis, GM1Allelesbeta-GalactosidaseCRISPR-Cas SystemsGene EditingHumansbeta-GalactosidaseGLB1 protein, human

Identifiers

PMID36629845
PMCPMC9986017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.