SynthesisAmerican journal of respiratory and critical care medicine2023
Minimal Clinically Important Difference in the 6-minute-walk Distance for Patients with Pulmonary Arterial Hypertension.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 6 pooled it
15.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Safety and efficacy of exercise training in patients with pulmonary hypertension: a systematic review and meta-analysis.European journal of applied physiology · 2026Pooled it
- Phosphodiesterase type 5 inhibitor plus endothelin receptor antagonist compared to either alone for group 1 pulmonary arterial hypertension.The Cochrane database of systematic reviews · 2025Pooled it
- The Placebo Effect in Chronic Thromboembolic Pulmonary Hypertension Trials: A Systematic Review and Meta-Analysis.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Effects of postoperative physical exercise rehabilitation on cardiorespiratory fitness, functional capacity and quality of life in patients with colorectal, breast, and prostate cancer - a systematic review and meta-analysis.Journal of cancer research and clinical oncology · 2024Pooled it
- Clinical Response to Pulmonary Arterial Hypertension Treatment Does Not Depend on Pulmonary Arterial Wedge Pressure: A Meta-Analysis Using Individual Participant Data from Randomized Clinical Trials.American journal of respiratory and critical care medicine · 2024Pooled it
- Heterogeneity of treatment effects by risk in pulmonary arterial hypertension.The European respiratory journal · 2023Pooled it
- Associations between 6-minute walk distance and physiologic measures and clinical outcomes in myositis-associated interstitial lung disease.Rheumatology (Oxford, England) · 2025Trial
- Randomised, placebo-controlled trial of oral hymecromone in adults with pulmonary hypertension.Thorax · 2025Trial
- Pulmonary Hypertension and Anastrozole (PHANTOM): A Randomized, Double-Blind, Placebo-Controlled Trial.American journal of respiratory and critical care medicine · 2024Trial
- MK-5475, an inhaled soluble guanylate cyclase stimulator, for treatment of pulmonary arterial hypertension: the INSIGNIA-PAH study.The European respiratory journal · 2024Trial
- Meaningful thresholds for change in quantitative computed tomography-derived fibrosis extent in idiopathic pulmonary fibrosis.American journal of respiratory and critical care medicine · 2026Article
- Pulmonary vascular reactivity in severe pulmonary hypertension associated with COPD.ERJ open research · 2026Article
- Effect of low-flow oxygen therapy on 6 minute walk test in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: a randomized non-inferiority crossover trial.European heart journal open · 2026Article
- Article
- Factors associated with variations in the 6-minute walk distance during the follow-up of patients with systemic sclerosis.Arthritis research & therapy · 2026Article
- Article
- Post-Pulmonary Embolism Syndrome: New Phenotypes Come into Focus.Journal of clinical medicine · 2026Review
- Longitudinal Remote 6-Minute Walk Distance and Cardiac Effort Using Wearable Sensors in Pulmonary Hypertension.Pulmonary circulation · 2026Article
- The role of imaging in risk assessment for pulmonary arterial hypertension.Current opinion in cardiology · 2025Review
- Characterization of the Population With Intermediate-Risk Status in Pulmonary Arterial Hypertension: Patients in a Latin American Country: The CAPRI Registry.Pulmonary circulation · 2025Article
Corrections and comments
- Commented on by
Authors and funding
12 authors at 7 institutions in 2 countries.
Jude MoutchiaDepartment of Biostatistics, Epidemiology, and Informatics and.
Robyn L McClellandDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, Washington.
Nadine Al-NaamaniDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Dina H ApplebyDepartment of Biostatistics, Epidemiology, and Informatics and.
Kristina BlankDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, Washington.
Dan GrinnanDepartment of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.
John H HolmesDepartment of Biostatistics, Epidemiology, and Informatics and.
Stephen C MathaiDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Jasleen MinhasDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0001-7864-6096
Corey E VentetuoloDepartments of Medicine and Health Services, Policy and Practice, Brown University, Providence, Rhode Island; and.
Roham T ZamanianDepartment of Medicine, School of Medicine, Stanford University, Palo Alto, California.
Steven M KawutDepartment of Biostatistics, Epidemiology, and Informatics and.
Institute for Medical Informatics and Biostatistics · CHUniversity of Pennsylvania · USUniversity of Washington · USBrown University · USJohns Hopkins University · USStanford University · USVirginia Commonwealth University · US
Funding
Cardiology & pulmonary research training grantT32HL007891 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Jason D Christie · 1998 to 2026
$12.0MMentored Patient-Oriented Research in Pulmonary Arterial HypertensionK24HL103844 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2011 to 2020
$1.6MObesity in Pulmonary Arterial HypertensionK23HL141584 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI AL-NAAMANI, NADINE · 2018 to 2022
$970kNHLBI NIH HHS K23 HL141584NHLBI NIH HHS K24 HL103844NHLBI NIH HHS T32 HL007891
Abstract
PubMed holds no abstract for this paper.
Indexed as
Hypertension, PulmonaryPulmonary Arterial HypertensionAdultAgedFamilial Primary Pulmonary HypertensionFemaleHumansMaleMiddle AgedMinimal Clinically Important DifferenceWalkingindividual participant data meta-analysisminimum important differencePAHwalk test
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.