Evidence map›Paper›PMID 36629597›Full record

ArticleArquivos brasileiros de cardiologia2023

ST-Segment Elevation Myocardial Infarction Differences between Genders - A Single Center Retrospective Analysis.

Cátia Costa Oliveira, Filipe Vilela, Carlos Braga, João Costa, Jorge Marques

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Article in Arquivos brasileiros de cardiologia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Cátia Costa OliveiraServiço de Cardiologia, Hospital de Braga, Braga - Portugal.ORCID 0000-0002-8010-6299
Filipe VilelaEscola de Medicina da Universidade do Minho, Braga - Portugal.
Carlos BragaServiço de Cardiologia, Hospital de Braga, Braga - Portugal.
João CostaServiço de Cardiologia, Hospital de Braga, Braga - Portugal.
Jorge MarquesServiço de Cardiologia, Hospital de Braga, Braga - Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary interventions (PCI) have improved, women show higher mortality.

objectivesTo assess gender differences in presentation, management and in-hospital mortality, at 30-days, 6-months and 1-year after STEMI.

methodsWe retrospectively collected data from 809 consecutive patients treated with primary PCI and compared the females versus males at the local intervention cardiology database. The level of significance used was p<0.05.

resultsWomen were older than man (69,1±14,6 vs. 58,5±12,7 years; p<.001) with higher prevalence of age over 75 years (36.7% vs. 11.7%; p<.001), diabetes (30,6% vs. 18,5%; p=.001), hypertension (60.5% vs. 45.9%; p=.001), chronic kidney disease (3.4% vs. 0.6%; p=.010) and acute ischemic stroke (6.8% vs. 3.0%; p=.021). At presentation, women had more atypical symptoms, less chest pain (p=.014) and were more frequently in cardiogenic shock (p=.011)). Women had longer time until reperfusion (p=.001) and were less likely to receive optimal medical therapy (p<0.05). In-hospital mortality (p=.001), at 30-days (p<.001), 6-months (p<.001) and 1-year (16.4% vs. p<.001) was higher in women. The multivariate analysis identified age over 75 years (HR=4.25; 95% CI[1.67-10.77];p=.002), Killip class II (HR=8.80; 95% CI[2.72-28.41];p<.001), III (HR=5.88; 95% CI [0.99-34.80]; p=.051) and IV (HR=9.60; 95% CI[1.86-48.59];p=.007), Acute Kidney Injury (HR=2.47; 95% CI[1.00-6.13];p=.051) and days of hospitalization (HR=1.04; 95% CI[1.01-1.08];p=.030) but not female gender (HR=0.83; 95% CI[0.33-2.10];p=.690) as independent prognostic factors of mortality.

conclusionsCompared to men, women with STEMI undergoing primary PCI have higher mortality rates. Women admitted for STEMI have a worse risk profile, are treated with a higher reperfusion time related with system delays and are less likely to receive the recommended therapy. Female gender was not an independent prognostic factor for mortality in the studied population.

Indexed as

Ischemic StrokeMyocardial InfarctionPercutaneous Coronary InterventionST Elevation Myocardial InfarctionAgedFemaleHospital MortalityHumansMaleRetrospective StudiesRisk FactorsTreatment Outcome

Identifiers

PMID36629597
PMCPMC9833215

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