ArticleJournal of the National Cancer Institute2023
Glyphosate exposure and urinary oxidative stress biomarkers in the Agricultural Health Study.
Article in Journal of the National Cancer Institute, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 77 citations in OpenAlex.
- Identification of chemicals targeting dementia genes and pathways in the Comparative Toxicogenomics Database.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Impact of glyphosate and its mixture with 2,4-D and dicamba on gut biochemical function, intestinal barrier integrity and microbiome composition in adult rats with prenatal commencement of exposure.Archives of toxicology · 2026Article
- Sex-Specific sRNA Signatures in Rat Liver Reveal Divergent Alterations Following Perinatal Exposure to Glyphosate and Its Mixture with 2,4-D and Dicamba.International journal of molecular sciences · 2026Article
- Comparing the Effects of Glyphosate and Mycotoxins in the Human Follicular Microenvironment: An Exploratory Exposome Study.Biomedicines · 2026Article
- Emerging risk identification in the food chain using text mining-supported monitoring of food safety news: insights from 2022 to 2023.Scientific reports · 2026Article
- How Glyphosate and Its Derivatives Influence Antimicrobial Resistance Emergence and Transmission: A One Health Perspective.Antibiotics (Basel, Switzerland) · 2026Review
- Association between Gestational Nitrated Polycyclic Aromatic Hydrocarbons Exposure Burden and Newborn Sizes: Mediating the Role of Placental 8‑OHdG.Environment & health (Washington, D.C.) · 2026Article
- Shared Plant-human Biology: Herbicide Effects and New Biomarkers Perspectives.Current environmental health reports · 2026Review
- Article
- Identification of chemicals targeting dementia genes and pathways in the Comparative Toxicogenomics Database.bioRxiv : the preprint server for biology · 2025Article
- Immunomodulatory effects of the herbicide glyphosate following occupational exposure.Archives of toxicology · 2025Article
- Global Evidence on Monitoring Human Pesticide Exposure.Journal of xenobiotics · 2025Review
- Multi-Omics Alterations in Rat Kidneys upon Chronic Glyphosate Exposure.Biomolecules · 2025Article
- The association between glyphosate use and mosaic loss of chromosome Y in buccal samples among male pesticide applicators in the Agricultural Health Study.Environment international · 2025Article
- Network toxicology reveals glyphosate mechanisms in kidney injury and cancer.Scientific reports · 2025Article
- Toxicological concerns regarding glyphosate, its formulations, and co-formulants as environmental pollutants: a review of published studies from 2010 to 2025.Archives of toxicology · 2025Review
- Trehalose prevents glyphosate-induced kidney damage in roosters via inhibiting apoptosis.Veterinary research communications · 2025Article
- Urinary Glyphosate Concentrations and Serum Sex Hormones in a Nationally Representative U.S. Sample: NHANES 2017-2018.Life (Basel, Switzerland) · 2025Article
- Carcinogenic effects of long-term exposure from prenatal life to glyphosate and glyphosate-based herbicides in Sprague-Dawley rats.Environmental health : a global access science source · 2025Article
- Effects of cultivating biotech maize GG2 and glyphosate treatment on the rhizospheric microbial community structure.aBIOTECH · 2025Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundGlyphosate is the most widely applied herbicide worldwide, and its use has been associated with increased risks of certain hematopoietic cancers in epidemiologic studies. Animal and in vitro experiments suggest that glyphosate may induce oxidative stress, a key characteristic of carcinogens; however, evidence in human populations remains scarce. We investigated associations between glyphosate exposure and urinary oxidative stress biomarkers in the Biomarkers of Exposure and Effect in Agriculture study, a molecular epidemiologic subcohort in the Agricultural Health Study.
methodsThis analysis included 268 male farmers selected based on self-reported recent and lifetime occupational glyphosate use and 100 age- and geography-matched male nonfarmers. Concentrations of glyphosate and oxidative stress biomarkers (8-hydroxy-2'-deoxyguanosine [8-OHdG], 8-iso-prostaglandin-F2α, and malondialdehyde [MDA]) were quantified in first-morning-void urine. We performed multivariable linear regression to evaluate associations of urinary glyphosate and self-reported glyphosate use with each oxidative stress biomarker.
resultsUrinary glyphosate concentrations were positively associated with levels of 8-OHdG (highest vs lowest glyphosate quartile; geometric mean ratio = 1.15, 95% confidence interval = 1.03 to 1.28; Ptrend = .02) and MDA (geometric mean ratio = 1.20, 95% confidence interval = 1.03 to 1.40; Ptrend = .06) overall. Among farmers reporting recent glyphosate use (last 7 days), use in the previous day was also associated with statistically significantly increased 8-OHdG and MDA levels. Compared with nonfarmers, we observed elevated 8-iso-prostaglandin-F2α levels among farmers with recent, high past 12-month, or high lifetime glyphosate use.
conclusionsOur findings contribute to the weight of evidence supporting an association between glyphosate exposure and oxidative stress in humans and may inform evaluations of the carcinogenic potential of this herbicide.
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