Evidence map›Paper›PMID 36629454›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2023

Synthesis, kinetic studies and

Muhammad Naeem Mustafa, Pervaiz Ali Channar, Muhammad Sarfraz, Aamer Saeed, Syeda Abida Ejaz, Mubashir Aziz, Fatmah Ali Alasmary, Hanadi Yaqob Alsoqair, Hussain Raza, Song Ja Kim and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
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  4. Current status ofRSC advances · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 5 countries.

Muhammad Naeem MustafaDepartment of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.
Pervaiz Ali ChannarDepartment of Basic sciences and Humanities, Dawood University of Engineering and Technology, Karachi, Pakistan.
Muhammad SarfrazCollege of Pharmacy, Al Ain Campus, Al Ain University, Al Ain, United Arab Emirates.ORCID 0000-0002-0516-4966
Aamer SaeedDepartment of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.ORCID 0000-0002-7112-9296
Syeda Abida EjazDepartment of Pharmaceutical Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Mubashir AzizDepartment of Pharmaceutical Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Fatmah Ali AlasmaryDepartment of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Hanadi Yaqob AlsoqairDepartment of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Hussain RazaDepartment of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, Republic of Korea.
Song Ja KimDepartment of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, Republic of Korea.
Asad HamadFaculty of Pharmacy, Grand Asian University Sialkot, Sialkot, Pakistan.
Islamia University of Bahawalpur · PKKing Saud University · SAKongju National University · KRQuaid-i-Azam University · PKAl Ain University · AEAsian University · THDawood University of Engineering and Technology · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deposition of hydroxyapatite (HA) or alkaline phosphate crystals on soft tissues causes the pathological calcification diseases comprising of end-stage osteoarthritis (OA), ankylosing spondylitis (AS), medial artery calcification and tumour calcification. The pathological calcification is symbolised by increased concentration of tissue non-specific alkaline phosphatase (TNAP). An efficient therapeutic strategy to eradicate these diseases is required, and for this the alkaline phosphatase inhibitors can play a potential role. In this context a series of novel quinolinyl iminothiazolines was synthesised and evaluated for alkaline phosphatase inhibition potential. All the compounds were subjected to DFT studies where

Indexed as

Alkaline PhosphataseEnzyme InhibitorsBenzamidesKineticsMolecular Docking SimulationAlkaline PhosphatasebenzamideBenzamidesEnzyme InhibitorsAlkaline phosphataseDFTkinetic analysismolecular dockingsynthesis

Identifiers

PMID36629454
PMCPMC9848371
OpenAlexW4315620074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.