Evidence map›Paper›PMID 36629452›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2023

An in silico toolbox for the prediction of the potential pathogenic effects of missense mutations in the dimeric region of

Giulio Poli, Gian Carlo Demontis, Andrea Sodi, Alessandro Saba, Stanislao Rizzo, Marco Macchia, Tiziano Tuccinardi

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Novel Insights on Benzo[Antioxidants (Basel, Switzerland) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Giulio PoliDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID 0000-0002-8061-5632
Gian Carlo DemontisDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID 0000-0001-7641-0426
Andrea SodiDepartment of Neurosciences, Psychology, Drug Research and Child Health Eye Clinic, University of Florence, AOU Careggi, Florence, Italy.
Alessandro SabaDepartment of Surgical Pathology, Molecular Medicine and of the Critical Area, University of Pisa, Pisa, Italy.ORCID 0000-0003-0611-5549
Stanislao RizzoOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.ORCID 0000-0001-6302-063X
Marco MacchiaDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Tiziano TuccinardiDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID 0000-0002-6205-4069
University of Pisa · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cis-trans-IsomerasesMutation, MissenseComputational BiologyHumansRetinoid Isomerohydrolasecis-trans-IsomerasesRetinoid Isomerohydrolasemissense mutationsmolecular dynamicsRPE65variant of uncertain significance (VUS)

Identifiers

PMID36629452
PMCPMC9848331
OpenAlexW4315620666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.