Evidence map›Paper›PMID 36629440›Full record

ArticleInfection and immunity2023

Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice.

Kaley M Wilburn, Rachel K Meade, Emma M Heckenberg, Jacob Dockterman, Jörn Coers, Christopher M Sassetti, Andrew J Olive, Clare M Smith

Open access · hybridAbstract read
In one paragraph

Article in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Autophagy and Bacterial infections.Autophagy reports · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Analysis of intestinal epithelial cell responses tobioRxiv : the preprint server for biology · 2023
    Article
  8. Type I IFN signaling in the absence of IRGM1 promotesbioRxiv : the preprint server for biology · 2023
    Article
  9. Article
  10. High Lethality ofInfection and immunity · 2023
    Article
  11. Article
  12. International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Kaley M WilburnDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-9007-3478
Rachel K MeadeDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-8322-0257
Emma M HeckenbergDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-3646-4283
Jacob DocktermanDepartment of Immunology, Duke University Medical Center, Durham, North Carolina, USA.
Jörn CoersDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-8707-4608
Christopher M SassettiDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Andrew J OliveDepartment of Microbiology and Molecular Genetics, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0003-3441-3113
Clare M SmithDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-2601-0955
Duke University · USDuke Medical Center · USMichigan State University · USUniversity of Massachusetts Chan Medical School · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Regional Biocontainment Laboratory (RBL)UC6AI058607 · NIAID · DUKE UNIVERSITY · PI WILLIAMS, R SANDERS · 2003 to 2005
$16.3M
Systems Genetics of TuberculosisP01AI132130 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2017 to 2021
$11.2M
Regional Biocontainment Laboratories Facility and Building System Upgrades SupportG20AI167200 · NIAID · DUKE UNIVERSITY · PI STAATS, HERMAN F · 2021 to 2022
$6.6M
Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
IRGM-driven host responses to Chlamydia trachomatis infectionsR01AI103197 · NIAID · DUKE UNIVERSITY · PI COERS, JOERN · 2013 to 2023
$4.2M
Genetics and Genomics Training GrantT32GM136627 · NIGMS · DUKE UNIVERSITY · PI ALLISON E ASHLEY-KOCH · 2020 to 2026
$3.1M
Regulators of IFN-gamma responses during Mycobacterium tuberculosis infectionR01AI165618 · NIAID · MICHIGAN STATE UNIVERSITY · PI Andrew Olive · 2022 to 2026
$2.6M
IRGM proteins as regulators of inflammationR01AI148243 · NIAID · DUKE UNIVERSITY · PI COERS, JOERN, TAYLOR, GREGORY A · 2020 to 2024
$2.4M
Interferon-inducible cell-intrinsic host defense against Chlamydia trachomatisR37AI103197 · NIAID · DUKE UNIVERSITY · PI Jorn Coers · 2024 to 2026
$1.6M
Dissecting the genetic basis of protective immunity to tuberculosis in diverse hostsDP2GM146458 · NIGMS · DUKE UNIVERSITY · PI SMITH, CLARE MARGARET · 2021 to 2021
$1.4M
Dissecting the genetic basis of protective immunity to tuberculosis in diverse hostsDP2AI183152 · NIAID · DUKE UNIVERSITY · PI SMITH, CLARE MARGARET · 2024 to 2024
$966k
NIAID NIH HHS DP2 AI183152NIAID NIH HHS G20 AI167200NIAID NIH HHS P01 AI132130NIAID NIH HHS R01 AI103197NIAID NIH HHS R01 AI148243NIAID NIH HHS R01 AI165618NIAID NIH HHS R37 AI103197NIAID NIH HHS UC6 AI058607NIGMS NIH HHS DP2 GM146458NIGMS NIH HHS T32 GM007171NIGMS NIH HHS T32 GM136627NIGMS NIH HHS T32 GM145449
6 · The paper itself

Abstract

Mycobacterium tuberculosis (

Indexed as

Latent TuberculosisMycobacterium tuberculosisTuberculosisAnimalsGTP-Binding ProteinsHumansMacrophagesMiceGTP-Binding ProteinsIRGM protein, humanhost geneticsinflammationIRGMtuberculosis

Identifiers

PMID36629440
PMCPMC9933630
OpenAlexW4315619895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.