Evidence map›Paper›PMID 36628985›Full record

Trial reportJournal of the American Heart Association2023

Effects of the Dietary Approaches to Stop Hypertension Diet on Change in Cardiac Biomarkers Over Time: Results From the DASH-Sodium Trial.

Matthew J Belanger, Lara C Kovell, Ruth-Alma Turkson-Ocran, Kenneth J Mukamal, Xiaoran Liu, Lawrence J Appel, Edgar R Miller, Frank M Sacks, Robert H Christenson, Heather Rebuck and 2 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthew J BelangerDivision of Cardiology, Department of Medicine Johns Hopkins Medical Institutions Baltimore MD.ORCID 0000-0003-1988-6289
Lara C KovellDivision of Cardiology University of Massachusetts Chan Medical School Worcester MA.ORCID 0000-0002-7919-2361
Ruth-Alma Turkson-OcranBeth Israel Deaconess Medical Center Harvard Medical School Boston MA.ORCID 0000-0001-9932-052X
Kenneth J MukamalBeth Israel Deaconess Medical Center Harvard Medical School Boston MA.ORCID 0000-0001-8450-6970
Xiaoran LiuHarvard T.H. Chan School of Public Health, Harvard Medical School Brigham and Women's Hospital Boston MA.ORCID 0000-0001-7356-645X
Lawrence J AppelThe Johns Hopkins University School of Medicine The Johns Hopkins Bloomberg School of Public Health, and The Welch Center for Prevention, Epidemiology and Clinical Research Baltimore MD.ORCID 0000-0002-0673-6823
Edgar R MillerThe Johns Hopkins University School of Medicine The Johns Hopkins Bloomberg School of Public Health, and The Welch Center for Prevention, Epidemiology and Clinical Research Baltimore MD.ORCID 0000-0003-0157-6258
Frank M SacksHarvard T.H. Chan School of Public Health, Harvard Medical School Brigham and Women's Hospital Boston MA.ORCID 0000-0003-1341-1995
Robert H ChristensonDepartment of Pathology University of Maryland School of Medicine Baltimore MD.ORCID 0000-0003-2612-9083
Heather RebuckDepartment of Pathology University of Maryland School of Medicine Baltimore MD.
Alex R ChangGeisinger Health Danville PA.ORCID 0000-0002-8114-7447
Stephen P JuraschekBeth Israel Deaconess Medical Center Harvard Medical School Boston MA.ORCID 0000-0003-4168-2696

Funding

Zoledronic Acid in Treatment of Osteoporosis in PostmenoM01RR002635 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A · 1985 to 2008
$48.4M
Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
UCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3M
Vitamin D, Subclinical Cardiovascular Disease, and Orthostatic Hypotension in Older AdultsK23HL135273 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2017 to 2021
$1.1M
The Effects of the DASH Diet and Sodium Reduction on Subclinical Cardiac DamageR21HL144876 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2018 to 2019
$263k
ZIDOVUDINE WITH PROBENECID--EFFECTS OF PROBENECID ON ZIDOVUDINEM01RR000722 · NCRR · JOHNS HOPKINS UNIVERSITY · PI MILLER, EDWARD D · 1985 to 1996
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NCRR NIH HHS M01 RR000722NCRR NIH HHS M01 RR002635NHLBI NIH HHS K23 HL135273NHLBI NIH HHS R21 HL144876NHLBI NIH HHS R25 HL145817NHLBI NIH HHS T32 HL007444
6 · The paper itself

Abstract

Background The Dietary Approaches to Stop Hypertension (DASH) diet has been shown to reduce biomarkers of cardiovascular disease. We aimed to characterize the time course of change in biomarkers of cardiac injury (high-sensitivity cardiac troponin I), cardiac strain (NT-proBNP [N-terminal pro-B-type natriuretic peptide]), and inflammation (hs-CRP [high-sensitivity C-reactive protein]) while consuming the DASH diet. Methods and Results The DASH-Sodium trial was a randomized controlled trial of 412 adults with elevated blood pressure or hypertension. Participants were randomly assigned to 12 weeks of the DASH diet or a typical American diet. Energy intake was adjusted to maintain body weight. Measurements of high-sensitivity cardiac troponin I, NT-proBNP, and hs-CRP were performed in stored serum specimens, collected at baseline and ≈4, 8, and 12 weeks after randomization. In both the control diet and DASH diet, levels of NT-proBNP decreased; however, there was no difference between diets (

Indexed as

Dietary Approaches To Stop HypertensionHypertensionAdultBiomarkersC-Reactive ProteinDietHumansInflammationNatriuretic Peptide, BrainPeptide FragmentsSodiumTroponin ITroponin TBiomarkersC-Reactive ProteinNatriuretic Peptide, BrainPeptide FragmentsSodiumTroponin ITroponin TbiomarkersDietary Approaches to Stop Hypertension diethigh‐sensitivity troponinhs‐CRP (high‐sensitivity C‐reactive protein)NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide)

Identifiers

PMID36628985
PMCPMC9939071

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.