ArticleJournal of the American Heart Association2023
Age-Dependent Association Between Modifiable Risk Factors and Incident Cardiovascular Disease.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Adherence to the DASH Diet in the Spanish Population and Its Environmental Impact: An Ecological Study.Nutrients · 2026Article
- Life stage-specific heterogeneity in the effects of adiposity transition on hypertension incidence and resolution.International journal of obesity (2005) · 2026Article
- Risk factor heterogeneity across cardiovascular disease outcomes in treatment-eligible hypertensive patients.Journal of hypertension · 2026Article
- Metabolic syndrome severity is related to perceived discrimination and stress in the all of us cohort.Comprehensive psychoneuroendocrinology · 2026Article
- Traditional and Emerging Lipid Markers for Cardiovascular Risk Assessment in Young vs Older Adults.JAMA network open · 2026Article
- Temporal Trends and Geographic Associations of Circulatory Disease Hospitalizations Among Young Adults in Almaty and the Turkestan Region, 2018-2024.Vascular health and risk management · 2026Article
- Associations of cardiometabolic burden with cardiovascular disease-death transitions in metabolic dysfunction-associated steatotic liver disease: a prospective cohort study using multistate analysis.Frontiers in nutrition · 2026Article
- Blood pressure control and treatment status at 1 year after the first health check-up in individuals with observed referral-level blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Revisiting obesity thresholds for cardiovascular disease and mortality risk in Chinese adults: Age- and gender-specific insights.Cell reports. Medicine · 2025Article
- Correlation of enlarged perivascular spaces in basal ganglion and cancer-associated stroke: a case-control study in China.Stroke and vascular neurology · 2025Article
- Large-scale genome-wide interaction analyses on multiple cardiometabolic risk factors to identify age-specific genetic risk factors.GeroScience · 2025Article
- Blood pressure and the brain: the conundrum of hypertension and dementia.Cardiovascular research · 2025Review
- Emerging New Era of Artificial Intelligence and Digital Medicine-directed Management of Chronic Kidney Disease.JMA journal · 2025Article
- Changes in Cardiovascular Health, Genetic Risk, and Cardiometabolic Diseases: Evidence From a Large-Scale Cohort Study.Journal of the American Heart Association · 2025Article
- Influence of prestroke glycemic status on outcomes by age in patients with acute ischemic stroke and diabetes mellitus.European journal of neurology · 2025Article
- Temporal relationship between inflammation and metabolic disorders and its influence on atherosclerotic cardiovascular disease.Frontiers in cardiovascular medicine · 2025Article
- Beyond prescriptions: chronic medication adherence predicts mortality risk in a large-scale cohort study.Frontiers in pharmacology · 2025Article
- Lifestyle-attributable burden of young-onset stroke in Chinese and global populations aged 20-54 years: A three decades comparative study (1990-2021) using Global Burden of Disease study data.Tobacco induced diseases · 2025Article
- The association of sexual frequency with cardiovascular diseases incidence and all-cause mortality.Scientific reports · 2024Article
- Atherosclerotic Cardiovascular Diseases Are Associated With Incident Metastatic and Nonmetastatic Cancer.JACC. CardioOncology · 2024Article
Corrections and comments
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background There have been limited data examining the age-dependent relationship of wide-range risk factors with the incidence of each subtype of cardiovascular disease (CVD) event. We assessed age-related associations between modifiable risk factors and the incidence of CVD. Methods and Results We analyzed 3 027 839 participants without a CVD history enrolled in the JMDC Claims Database (mean age, 44.8±11.0 years; 57.6% men). Each participant was categorized as aged 20 to 49 years (n=2 008 559), 50 to 59 years (n=712 273), and 60 to 75 years (n=307 007). Using Cox proportional hazards models and the relative risk reduction, we identified associations between risk factors and incident CVD, consisting of myocardial infarction, angina pectoris, stroke, and heart failure (HF). We assessed whether the association of risk factors for developing CVD would be modified by age category. Over a mean follow-up of 1133 days, 6315 myocardial infarction, 56 447 angina pectoris, 28 079 stroke, and 56 369 HF events were recorded. The incidence of myocardial infarction, angina pectoris, stroke, and HF increased with age category. Hazard ratios of obesity, hypertension, and diabetes in the multivariable Cox regression analyses for myocardial infarction, angina pectoris, stroke, and HF decreased with age category. The relative risk reduction of obesity, hypertension, and diabetes for CVD events decreased with age category. For example, the relative risk reduction of hypertension for HF decreased from 59.2% in participants aged 20 to 49 years to 38.1% in those aged 60 to 75 years. Conclusions The contribution of modifiable risk factor to the development of CVD is greater in younger compared with older individuals. Preventive efforts for risk factor modification may be more effective in younger people.
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