Evidence map›Paper›PMID 36628969›Full record

Trial reportHypertension (Dallas, Tex. : 1979)2023

The Proportion of Dietary Salt Replaced With Potassium-Enriched Salt in the SSaSS: Implications for Scale-Up.

Xuejun Yin, Ellie Paige, Maoyi Tian, Qiang Li, Liping Huang, Jie Yu, Anthony Rodgers, Paul Elliott, Yangfeng Wu, Bruce Neal

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Hypertension (Dallas, Tex. : 1979), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02092090 (A LARGE-SCALE CLUSTER RANDOMIZED TRIAL TO DETERMINE THE EFFECTS OF SODIUM REDUCTION ON STROKE), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02092090 nacompletednot on this map

A LARGE-SCALE CLUSTER RANDOMIZED TRIAL TO DETERMINE THE EFFECTS OF SODIUM REDUCTION ON STROKE: THE CHINA SALT SUBSTITUTE AND STROKE STUDY (SSaSS)

TypeinterventionalSponsorThe George InstituteRan2014 to 2020Enrolled20,996ConditionsStrokeArmsDietary sodium reduction
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Role of dietary potassium and salt substitution in the prevention and management of hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Potassium: To Add or to Replace…That Is the Question.Hypertension (Dallas, Tex. : 1979) · 2023
    Article
  13. Less sodium and more potassium to reduce cardiovascular risk.European heart journal supplements : journal of the European Society of Cardiology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Xuejun YinThe George Institute for Global Health, University of New South Wales, Sydney, Australia (X.Y., E.P., M.T., Q.L., L.H., J.Y., A.R., B.N.).ORCID 0000-0001-8446-9591
Ellie PaigeThe George Institute for Global Health, University of New South Wales, Sydney, Australia (X.Y., E.P., M.T., Q.L., L.H., J.Y., A.R., B.N.).
Maoyi TianThe George Institute for Global Health, University of New South Wales, Sydney, Australia (X.Y., E.P., M.T., Q.L., L.H., J.Y., A.R., B.N.).ORCID 0000-0002-5660-8571
Qiang LiThe George Institute for Global Health, University of New South Wales, Sydney, Australia (X.Y., E.P., M.T., Q.L., L.H., J.Y., A.R., B.N.).
Liping HuangThe George Institute for Global Health, University of New South Wales, Sydney, Australia (X.Y., E.P., M.T., Q.L., L.H., J.Y., A.R., B.N.).ORCID 0000-0002-0945-8988
Jie YuThe George Institute for Global Health, University of New South Wales, Sydney, Australia (X.Y., E.P., M.T., Q.L., L.H., J.Y., A.R., B.N.).ORCID 0000-0002-7401-7580
Anthony RodgersThe George Institute for Global Health, University of New South Wales, Sydney, Australia (X.Y., E.P., M.T., Q.L., L.H., J.Y., A.R., B.N.).
Paul ElliottSchool of Public Health, Imperial College London, UK (P.E., B.N.).ORCID 0000-0002-7511-5684
Yangfeng WuPeking University Clinical Research Institute, Peking University First Hospital, Beijing, China (Y.W.).ORCID 0000-0002-4451-1932
Bruce NealThe George Institute for Global Health, University of New South Wales, Sydney, Australia (X.Y., E.P., M.T., Q.L., L.H., J.Y., A.R., B.N.).ORCID 0000-0002-0490-7465
The George Institute for Global Health · AUPeking University · CNAustralian National University · AUChinese Academy of Medical Sciences & Peking Union Medical College · CNHarbin Medical University · CNPublic Health England · GBThe George Institute for Global Health · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe SSaSS (Salt Substitute and Stroke Study) recently reported definitive effects of a potassium-enriched salt on cardiovascular outcomes and death. Quantifying the amount of potassium-enriched salt used by trial participants is important for understanding the magnitude of the effect of potassium-enriched salt on risk reduction and how population-wide scale-up might be achieved.

methodsBaseline and annual 24-hour urine samples were collected from subgroups of participants in SSaSS throughout the 5-year follow-up. The mean difference in 24-hour potassium excretion between the 2 groups was used to estimate the quantity of potassium-enriched salt consumed in the intervention group. The corresponding projected difference in sodium intake between groups was calculated and compared with the observed difference.

resultsThe potassium-enriched salt group, compared to the regular salt group, had a mean increase in 24-hour urinary potassium excretion of 0.80 g/d (95% CI, 0.71-0.90), which equates to consumption of 8.8 g/d (95% CI, 7.8-9.9) of potassium-enriched salt. Based on 8.8 g/d potassium-enriched salt consumption, the projected difference in 24-hour urinary sodium excretion was -0.79 g/d. This compares to an observed difference of -0.35 g/d (95% CI, -0.55 to -0.15) and suggests that 72% of baseline regular salt intake was replaced by potassium-enriched salt.

conclusionsThe smaller than anticipated between-group difference in sodium excretion likely results from the joint use of regular salt and potassium-enriched salt in the intervention group. Our findings suggest that even an incomplete replacement of regular salt with potassium-enriched salt can deliver significant health gains. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT02092090.

Indexed as

PotassiumSodium, DietaryHumansPotassium ChlorideSodiumSodium ChlorideSodium Chloride, DietaryPotassiumPotassium ChlorideSodiumSodium ChlorideSodium Chloride, DietarySodium, Dietaryblood pressurecardiovascular diseasespotassium chloridesodium chloride

Identifiers

PMID36628969
OpenAlexW4315619356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.