Evidence map›Paper›PMID 36628928›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2023

Environmentally persistent free radicals enhance SARS-CoV-2 replication in respiratory epithelium.

Ayaho Yamamoto, Peter D Sly, Keng Yih Chew, Lavrent Khachatryan, Nelufa Begum, Abrey J Yeo, Luan D Vu, Kirsty R Short, Stephania A Cormier, Emmanuelle Fantino

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ayaho YamamotoChild Health Research Centre, The University of Queensland, South Brisbane, QLD 4101, Australia.ORCID 0000-0001-5143-4608
Peter D SlyChild Health Research Centre, The University of Queensland, South Brisbane, QLD 4101, Australia.
Keng Yih ChewSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4067, Australia.
Lavrent KhachatryanDepartment of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.ORCID 0000-0002-8067-7964
Nelufa BegumChild Health Research Centre, The University of Queensland, South Brisbane, QLD 4101, Australia.
Abrey J YeoChild Health Research Centre, The University of Queensland, South Brisbane, QLD 4101, Australia.
Luan D VuDepartment of Biological Sciences, and Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70803, USA.ORCID 0000-0001-8493-1811
Kirsty R ShortSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4067, Australia.
Stephania A CormierDepartment of Biological Sciences, and Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70803, USA.ORCID 0000-0002-6050-6172
Emmanuelle FantinoChild Health Research Centre, The University of Queensland, South Brisbane, QLD 4101, Australia.
The University of Queensland · AUPennington Biomedical Research Center · USLouisiana State University · US

Funding

Role of microbiota in increased influenza severity due to particulate matter exposureP42ES013648 · NIEHS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI LOMNICKI, SLAWO M · 2009 to 2024
$27.6M
NIEHS NIH HHS P42 ES013648
6 · The paper itself

Abstract

Epidemiological evidence links lower air quality with increased incidence and severity of COVID-19; however, mechanistic data have yet to be published. We hypothesized air pollution-induced oxidative stress in the nasal epithelium increased viral replication and inflammation. Nasal epithelial cells (NECs), collected from healthy adults, were grown into a fully differentiated epithelium. NECs were infected with the ancestral strain of SARS-CoV-2. An oxidant combustion by-product found in air pollution, the environmentally persistent free radical (EPFR) DCB230, was used to mimic pollution exposure four hours prior to infection. Some wells were pretreated with antioxidant, astaxanthin, for 24 hours prior to EPFR-DCB230 exposure and/or SARS-CoV-2 infection. Outcomes included viral replication, epithelial integrity, surface receptor expression (

Indexed as

COVID-19SARS-CoV-2Angiotensin-Converting Enzyme 2AntioxidantsCytokinesFree RadicalsHumansOxidantsRespiratory MucosaTumor Necrosis Factor-alphaXanthophyllsAngiotensin-Converting Enzyme 2AntioxidantsastaxanthineCytokinesFree RadicalsOxidantsTumor Necrosis Factor-alphaXanthophyllsair-liquid interface cultureantioxidantastaxanthinCOVID-19environmentally persistent free radicalsoxidative stress

Identifiers

PMID36628928
PMCPMC9836833
OpenAlexW4315567404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.