Evidence map›Paper›PMID 36628796›Full record

ArticleArtificial intelligence in medicine2023

Environmental exposures in machine learning and data mining approaches to diabetes etiology: A scoping review.

Sejal Mistry, Naomi O Riches, Ramkiran Gouripeddi, Julio C Facelli

Open access · greenAbstract readScoping Review
In one paragraph

Article in Artificial intelligence in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Metabolic syndrome and a broken heart: trust your gut or risk your heart.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sejal MistryDepartment of Biomedical Informatics, University of Utah, Salt Lake City, UT, USA; Center of Excellence for Exposure Health Informatics, University of Utah, Salt Lake City, UT, USA.
Naomi O RichesDepartment of Biomedical Informatics, University of Utah, Salt Lake City, UT, USA; Center of Excellence for Exposure Health Informatics, University of Utah, Salt Lake City, UT, USA; Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Ramkiran GouripeddiDepartment of Biomedical Informatics, University of Utah, Salt Lake City, UT, USA; Center of Excellence for Exposure Health Informatics, University of Utah, Salt Lake City, UT, USA; Clinical and Translational Science Institute, University of Utah, Salt Lake City, UT, USA.
Julio C FacelliDepartment of Biomedical Informatics, University of Utah, Salt Lake City, UT, USA; Center of Excellence for Exposure Health Informatics, University of Utah, Salt Lake City, UT, USA; Clinical and Translational Science Institute, University of Utah, Salt Lake City, UT, USA. Electronic address: julio.facelli@utah.edu.
University of Utah · US

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
UNIVERSITY OF UTAH MEDICAL INFORMATICS TRAININGT15LM007124 · NLM · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Karen Louise Eilbeck · 1997 to 2026
$22.0M
University of Utah Center for Clinical and Translational ScienceUL1TR001067 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$19.8M
University of Utah Interdisciplinary Training Program in Computational Approaches to Diabetes and Metabolism ResearchT32DK110966 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Karen Louise Eilbeck, Marcus Guy Pezzolesi · 2016 to 2026
$2.6M
Identifying Temporal Sequences of Exposures in Type 1 Diabetes EtiologyF30DK134113 · NIDDK · UNIVERSITY OF UTAH · PI MISTRY, SEJAL · 2022 to 2024
$144k
NCATS NIH HHS UL1 TR001067NCATS NIH HHS UL1 TR002538NIDDK NIH HHS F30 DK134113NIDDK NIH HHS T32 DK110966NLM NIH HHS T15 LM007124
6 · The paper itself

Abstract

backgroundEnvironmental exposures are implicated in diabetes etiology, but are poorly understood due to disease heterogeneity, complexity of exposures, and analytical challenges. Machine learning and data mining are artificial intelligence methods that can address these limitations. Despite their increasing adoption in etiology and prediction of diabetes research, the types of methods and exposures analyzed have not been thoroughly reviewed.

objectiveWe aimed to review articles that implemented machine learning and data mining methods to understand environmental exposures in diabetes etiology and disease prediction.

methodsWe queried PubMed and Scopus databases for machine learning and data mining studies that used environmental exposures to understand diabetes etiology on September 19th, 2022. Exposures were classified into specific external, general external, or internal exposures. We reviewed machine learning and data mining methods and characterized the scope of environmental exposures studied in the etiology of general diabetes, type 1 diabetes, type 2 diabetes, and other types of diabetes.

resultsWe identified 44 articles for inclusion. Specific external exposures were the most common exposures studied, and supervised models were the most common methods used. Well-established specific external exposures of low physical activity, high cholesterol, and high triglycerides were predictive of general diabetes, type 2 diabetes, and prediabetes, while novel metabolic and gut microbiome biomarkers were implicated in type 1 diabetes. DISCUSSION: The use of machine learning and data mining methods to elucidate environmental triggers of diabetes was largely limited to well-established risk factors identified using easily explainable and interpretable models. Future studies should seek to leverage machine learning and data mining to explore the temporality and co-occurrence of multiple exposures and further evaluate the role of general external and internal exposures in diabetes etiology.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Artificial IntelligenceData MiningEnvironmental ExposureHumansMachine LearningData miningDiabetes mellitusEnvironmental exposuresMachine learning

Identifiers

PMID36628796
PMCPMC9834645
OpenAlexW4311174821

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.