Evidence map›Paper›PMID 36628617›Full record

ArticleObesity (Silver Spring, Md.)2023

Obesity and metabolic dysfunction correlate with background parenchymal enhancement in premenopausal women.

Justin C Brown, Jennifer A Ligibel, Tracy E Crane, Despina Kontos, Shengping Yang, Emily F Conant, Julie A Mack, Rexford S Ahima, Kathryn H Schmitz

Open access · bronzeAbstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Justin C BrownPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID 0000-0001-7540-4913
Jennifer A LigibelDana-Farber Cancer Institute, Boston, Massachusetts, USA.
Tracy E CraneMiller School of Medicine, University of Miami, Miami, Florida, USA.
Despina KontosUniversity of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Shengping YangPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Emily F ConantUniversity of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Julie A MackPenn State College of Medicine, Hershey, Pennsylvania, USA.
Rexford S AhimaDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kathryn H SchmitzPenn State College of Medicine, Hershey, Pennsylvania, USA.
Pennington Biomedical Research Center · USPenn State Milton S. Hershey Medical Center · USUniversity of Pennsylvania · USDana-Farber Cancer Institute · USJohns Hopkins University · USUniversity of Miami · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2005 to 2026
$26.5M
WISER SisterR01CA131333 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SCHMITZ, KATHRYN H. · 2008 to 2012
$3.2M
NCI NIH HHS R01 CA131333NIDDK NIH HHS P30 DK072476NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

objectiveThis study tested the hypothesis that obesity and metabolic abnormalities correlate with background parenchymal enhancement (BPE), the volume and intensity of enhancing fibroglandular breast tissue on dynamic contrast-enhanced magnetic resonance imaging.

methodsParticipants included 59 premenopausal women at high risk of breast cancer. Obesity was defined as BMI ≥ 30 kg/m

resultsBMI was positively correlated with BPE (r = 0.69; p < 0.001); participants with obesity had higher BPE than those without obesity (404.9 ± 189.6 vs. 261.8 ± 143.8 cm

conclusionsIn premenopausal women at high risk of breast cancer, increased BPE is associated with obesity, insulin resistance, leptin, and adiponectin.

Indexed as

Breast NeoplasmsInsulin ResistanceAdiponectinFemaleHumansInflammationLeptinLipidsObesityAdiponectinLeptinLipids

Identifiers

PMID36628617
PMCPMC10141499
OpenAlexW4315619491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.