ArticleAmerican journal of cancer research2022
High ALDH2 expression is associated with better prognosis in patients with gastric cancer.
Article in American journal of cancer research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- [Research progress of aldehyde dehydrogenase type 2 in head and neck malignant tumors].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Review
- Expression pattern and prognostic significance of aldehyde dehydrogenase 2 in lung adenocarcinoma as a potential predictor of immunotherapy efficacy.Cancer innovation · 2025Article
- New insights into the role of tetraspanin 6, 7, and 8 in physiology and pathology.Cancer medicine · 2024Review
- ALDH2 is a novel biomarker and exerts an inhibitory effect on melanoma.Scientific reports · 2024Article
- Deciphering the role of tryptophan metabolism-associated genes ECHS1 and ALDH2 in gastric cancer: implications for tumor immunity and personalized therapy.Frontiers in immunology · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship among alcohol, acetaldehyde, and gastric cancer (GC) is a very interesting research direction. Although many studies have focused on the correlation between ALDH2 polymorphism and GC, ALDH2 expression in GC and its relationship with the prognosis of GC patients remain to be fully understood. To explore these, 455 GC cases were included in this study. The relationships of ALDH2 expression with patients' survival and clinicopathological characteristics were assessed. The immune infiltration characteristics of ALDH2 in GC were also analyzed. Furthermore, the gene regulatory network and functional pathways of ALDH2 in GC were investigated. We found that high expression of ALDH2 was associated with better prognosis in GC patients. GC patients with high ALDH2 expression had a lower degree of pathological malignancy, consistent with our hypothesis that ALDH2 may play as a tumor suppressor role in GC. Mechanistically, ALDH2 may cooperate with genes such as C5orf32, TSPAN8 and RILP to inhibit GC progression via regulating multiple signaling pathways and chemical carcinogenesis. Therefore, our study suggested that ALDH2, an important variant gene in Asians, might serve as a prognostic marker and a potential therapeutic target for patients with GC.
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Identifiers
36628272PMC9827082W4315619334What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.