ArticleAmerican journal of translational research2022
Development and validation of a novel diagnostic model for musculoskeletal aging (sarcopenia) based on cuproptosis-related genes associated with immunity.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Cuproptosis: Biomarkers, Mechanisms and Treatments in Diseases.Molecules (Basel, Switzerland) · 2026Review
- Potential relationship between cuproptosis and sepsis-acquired weakness: an intermediate role for mitochondria.Frontiers in physiology · 2025Review
- Cuproptosis and its potential role in musculoskeletal disease.Frontiers in cell and developmental biology · 2025Review
- Inflammation centered muscle signature of sarcopenia from postmenopausal women in Shanghai China.Frontiers in cell and developmental biology · 2025Article
- Emerging insights into cuproptosis and copper metabolism: implications for age-related diseases and potential therapeutic strategies.Frontiers in aging neuroscience · 2024Review
- The Effect ofDermatopathology (Basel, Switzerland) · 2023Article
- Identification of the cuproptosis-related hub genes and therapeutic agents for sarcopenia.Frontiers in genetics · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSarcopenia is a geriatric disease characterized by accelerated skeletal muscle mass and function loss due to aging. Cell death plays a pivotal role in the onset and progress of sarcopenia. The purpose of this study was to investigate the role of cuproptosis-related genes (CRGs) and immune infiltration in sarcopenia development.
methodsThree microarray expression datasets from the Gene Expression Omnibus (GEO) database were merged and batch-corrected by R software to identify differentially expressed genes (DEGs) between old and young skeletal muscles. Subsequently, DEGs were subjected to functional enrichment and gene set enrichment analysis (GSEA) to investigate the roles of DEGs and immune infiltration in the pathogenesis of musculoskeletal aging. Then, ssGSEA was performed to calculate the proportion of immune cells and functions within each muscle sample to analyze the differences between the older and young healthy muscle groups. In order to select candidate CRGs, the correlation between CRGs and immune infiltration was analyzed. Finally, a novel nomogram model of musculoskeletal aging was constructed based on candidate CRGs associated with immunity. Additionally, the diagnostic model based on key CRGs was tested using a validation dataset, and its diagnostic performance was evaluated by the area under curve (AUC) value.
results141 DEGs were identified between 45 older samples and 50 young healthy samples. Compared to young healthy muscle tissues, significantly lower infiltration levels of T-regulatory cells were identified in older muscle tissues, while dendritic cells (DCs) and mast cells were relatively higher. Based on the CRGs from seven candidates, a novel model with high prediction efficiency (AUC = 0.856) was established to diagnose and screen for sarcopenia.
conclusionThe CRGs associated with immunity may play a vital role in the development of musculoskeletal aging, providing a novel avenue for early diagnosis. Furthermore, immune cell infiltration is essential for the progression of musculoskeletal aging.
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Identifiers
36628249PMC9827334W4315619365What OpenQuestion holds
Registered trials
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