ArticleAmerican journal of translational research2022
The diagnostic value of combined detection of microRNA-155, TNF-α and IL-37 for active pulmonary tuberculosis in the elderly.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed, 1 citations in OpenAlex.
- miRNA in Diagnosis and Therapeutics of Tuberculosis: Importance in Latent and Brain Associated Pathologies.Current pharmaceutical design · 2026Review
- Interleukin-37 in respiratory diseases: molecular mechanisms and immune modulation.Frontiers in immunology · 2025Review
- Decoding the exosomal nucleic acid delivery system axis of macrophage autophagy and immune reprogramming via multi-omics analysis.Frontiers in molecular biosciences · 2025Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify a panel of potential biomarkers consisting of microRNA-155 (miR-155), tumor necrosis factor-alpha (TNF-α), interleukin-37 (IL-37) for the diagnosis of active pulmonary tuberculosis (PTB) infection in elderly patients.
methodsThe serum expression of miR-155 and TNF-α in patients was measured by RT-qPCR, and the serum IL-37 level was determined by ELISA. The correlation between their expression and the features of active PTB patients was also analyzed. The AUCs of miR-155, TNF-α and IL-37 in diagnosing active PTB was calculated according to the ROC curves. The sensitivity, specificity and Youden's index of the three biomarkers alone or in combination for the active PTB diagnosis in the elderly were assessed.
resultsmiR-155, TNF-α, and IL-37 were overexpressed in the sera of elderly patients with active PTB. miR-155, TNF-α and IL-37 serum levels were enhanced in the elderly patients with pulmonary and extrapulmonary TB relative to those with PTB only, and in patients with active TB infection in both lungs compared to those with unilateral lung infection. The AUCs of miR-155, TNF-α and IL-37 for the diagnosis of active PTB were 0.7920, 0.8734 and 0.7398, respectively. The combination of these three improved the sensitivity of the diagnosis (84.78%).
conclusionmiR-155, TNF-α and IL-37 were overexpressed in elderly patients with active PTB. The combined detection of serum miR-155/TNF-α/IL-37 expression has potential to serve as a diagnostic tool for active PTB in the elderly.
Indexed as
Identifiers
36628207PMC9827330W4315619138What OpenQuestion holds
Registered trials
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