Evidence map›Paper›PMID 36627736›Full record

ReviewKorean circulation journal2023

Strategy of Patient-Specific Therapeutics in Cardiovascular Disease Through Single-Cell RNA Sequencing.

Yunseo Jung, Juyeong Kim, Howon Jang, Gwanhyeon Kim, Yoo-Wook Kwon

Abstract readReview
In one paragraph

Review in Korean circulation journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yunseo Jung *Strategic Center of Cell and Bio Therapy for Heart, Diabetes & Cancer, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-2347-0059
Juyeong Kim *Department of Medicine, Seoul National University College of Medicine, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0000-0003-2018-2190
Howon Jang *Department of Medicine, Seoul National University College of Medicine, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0000-0001-7132-7017
Gwanhyeon KimDepartment of Medicine, Seoul National University College of Medicine, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0000-0002-9129-2517
Yoo-Wook KwonStrategic Center of Cell and Bio Therapy for Heart, Diabetes & Cancer, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-2418-429X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, single cell RNA sequencing (scRNA-seq) technology has enabled the discovery of novel or rare subtypes of cells and their characteristics. This technique has advanced unprecedented biomedical research by enabling the profiling and analysis of the transcriptomes of single cells at high resolution and throughput. Thus, scRNA-seq has contributed to recent advances in cardiovascular research by the generation of cell atlases of heart and blood vessels and the elucidation of mechanisms involved in cardiovascular development and diseases. This review summarizes the overall workflow of the scRNA-seq technique itself and key findings in the cardiovascular development and diseases based on the previous studies. In particular, we focused on how the single-cell sequencing technology can be utilized in clinical field and precision medicine to treat specific diseases.

Indexed as

Clinical applicationHeart developmentPrecision medicineSingle cell RNA sequencing

Identifiers

PMID36627736
PMCPMC9834554

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.