Evidence map›Paper›PMID 36627679›Full record

ArticleHarm reduction journal2023

Perspectives on long-acting injectable HIV antiretroviral therapy at an alternative care site: a qualitative study of people with HIV experiencing substance use and/or housing instability.

Laura Fletcher, Shana A B Burrowes, Ghulam Karim Khan, Lora Sabin, Samantha Johnson, Simeon D Kimmel, Glorimar Ruiz-Mercado, Cassandra Pierre, Mari-Lynn Drainoni

Open access · goldAbstract read
In one paragraph

Article in Harm reduction journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

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  17. At the intersection of trust and mistrust: A qualitative analysis of motivators and barriers to research participation at a safety-net hospital.Health expectations : an international journal of public participation in health care and health policy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Laura FletcherSection of Infectious Diseases, Boston Medical Center, 801 Massachusetts Avenue, Crosstown Building, 2nd Floor, Room 2015A, Boston, MA, 02118, USA. laura.fletcher@bmc.org.
Shana A B BurrowesSection of Infectious Diseases, Department of Medicine, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, Boston, USA.
Ghulam Karim KhanSection of General Internal Medicine, Boston Medical Center, Boston, USA.
Lora SabinDepartment of Global Health, Boston University School of Public Health, Boston, USA.
Samantha JohnsonSection of Infectious Diseases, Boston Medical Center, 801 Massachusetts Avenue, Crosstown Building, 2nd Floor, Room 2015A, Boston, MA, 02118, USA.
Simeon D KimmelSection of Infectious Diseases, Section of General Internal Medicine, Boston Medical Center, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, Boston, USA.
Glorimar Ruiz-MercadoSection of Infectious Diseases, Boston Medical Center, 801 Massachusetts Avenue, Crosstown Building, 2nd Floor, Room 2015A, Boston, MA, 02118, USA.
Cassandra PierreSection of Infectious Diseases, Department of Medicine, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, Boston, USA.
Mari-Lynn DrainoniSection of Infectious Diseases, Boston Medical Center, 801 Massachusetts Avenue, Crosstown Building, 2nd Floor, Room 2015A, Boston, MA, 02118, USA.
Boston University · USBoston Medical Center · US

Funding

Retention and Re-Engagement in Treatment for Addiction following Serious Injection Related Infections (RETAIN)K23DA054363 · NIDA · BOSTON MEDICAL CENTER · PI KIMMEL, SIMEON · 2021 to 2025
$947k
NIDA NIH HHS K23 DA054363
6 · The paper itself

Abstract

introductionAdherence to daily oral antiretroviral therapy (ART) and regular clinic appointments can be challenging for individuals who experience adverse social determinants of health. Long-acting injectable ART administered outside of traditional clinic settings may be a promising solution to adherence barriers, but additional research is needed to assess patients' perspectives. This study assessed perspectives of people living with HIV (PLWH) who had difficulty with adherence to traditional HIV care models and evaluated feasibility and acceptability of receiving a long-acting ART injection at a location outside of a traditional HIV clinic to address barriers to HIV care.

methodsQualitative interviews (n = 26) were conducted with PLWH who had experienced barriers to adherence. Participants were referred to the study by staff from Project Trust, a drop in harm reduction and sexually transmitted infection/HIV clinic. The interviews were conducted between May and November 2021. Interviews were recorded, professionally transcribed, coded, and analyzed qualitatively using the integrated-Promoting Action on Research Implementation in Health Services framework.

resultsWe identified 6 main themes regarding the acceptability of receiving a long-acting injection to treat HIV, and the acceptability and feasibility of receiving injections at an alternative care site. Participants specified that they: (1) have a general understanding about their HIV care and the importance of ART adherence, (2) prefer a long-acting injection over a daily pill regimen, (3) expressed concerns about injection safety and efficacy, (4) had specific logistical aspects around the delivery of long-acting injections, including location of injection administration, that they believed would improve their ability to adhere, (5) have confidence that they can become undetectable and then complete the oral lead-in required to begin receiving the injection, and (6) see potential barriers that remain a concern for successful adherence to long-acting injections.

conclusionTo better treat HIV among people who are living with challenging social determinants of health, interventions that include a long-acting injection in a non-traditional care setting may prove to be a promising treatment option.

Indexed as

Anti-HIV AgentsHIV InfectionsSubstance-Related DisordersAnti-Retroviral AgentsHIVHousing InstabilityHumansMedication AdherenceAnti-HIV AgentsAnti-Retroviral AgentsAdherenceCare delivery modelsHIVHomelessnessLong-acting injectable ARTQualitativeSubstance use

Identifiers

PMID36627679
PMCPMC9830853
OpenAlexW4315483961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.