Evidence map›Paper›PMID 36627650›Full record

ArticleLaboratory animal research2023

Comparison of immunophenotypes between Rag2 knockout mice derived from two different sources.

Yu Jeong Roh, Jeong Eun Gong, Ji Eun Kim, You Jeong Jin, Hee Jin Song, Ayun Seol, Jumin Park, Yong Lim, Dae Youn Hwang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laboratory animal research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yu Jeong Roh *Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animal Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang, 50463, Korea.
Jeong Eun Gong *Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animal Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang, 50463, Korea.
Ji Eun KimDepartment of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animal Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang, 50463, Korea.
You Jeong JinDepartment of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animal Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang, 50463, Korea.
Hee Jin SongDepartment of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animal Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang, 50463, Korea.
Ayun SeolDepartment of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animal Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang, 50463, Korea.
Jumin ParkDepartment of Food Science and Nutrition, College of Human Ecology, Pusan National University, Busan, 46241, Korea.
Yong LimDepartment of Clinical Laboratory Science, College of Nursing and Healthcare Science, Dong-Eui University, Busan, 47340, Korea.
Dae Youn HwangDepartment of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animal Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang, 50463, Korea. dyhwang@pusan.ac.kr.ORCID http://orcid.org/0000-0002-5144-1725
Pusan National University · KRDong-Eui University · KR

Funding

Ministry of Food and Drug Safety grant of NLAR (National Laboratory Animal Resources)National Research Foundation of Korea F22YY8109033
6 · The paper itself

Abstract

backgroundRecombination activating gene2 (Rag2) knockout (KO) mice are used widely in various research fields, including vaccine development, transplantation studies, and hematopoiesis research, but few studies have compared their phenotypes. This study examined whether there were differences in the immunophenotypes between Rag2 KO mice derived from different sources. In particular, the changes in the organ weight, histological structure, and subpopulation of T and B cells were compared in the spleen and thymus of C57BL/6-Rag2

resultsThe weight of the spleen and thymus similarly decreased in the Rag2/Korl and Rag2/J KO mice compared to their wild type (WT) mice, even though the other organs were kept at the same weight. A slight difference between the Rag2/Korl and Rag2/J KO group were detected in the number of white blood cells (WBC), lymphocytes (LYM), red cell distribution width (RDW), and platelets (PLT). In addition, the white pulp of the spleen and the cortex region of the thymus decreased in both Rag2 KO mice compared to WT mice. On the other hand, significant differences in the number of CD8

conclusionsThese results suggest that Rag2/Korl and Rag2/J KO mice exhibit similar immunophenotypes in the spleen and thymus except for the differences in the number of CD8

Indexed as

B cellsImmunophenotypesKnockout miceRag2SpleenT cellsThymus

Identifiers

PMID36627650
PMCPMC9832259
OpenAlexW4315620634

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.