Evidence map›Paper›PMID 36627576›Full record

ArticleBMC pregnancy and childbirth2023

Mechanical ventilation and death in pregnant patients admitted for COVID-19: a prognostic analysis from the Brazilian COVID-19 registry score.

Zilma Silveira Nogueira Reis, Magda Carvalho Pires, Lucas Emanuel Ferreira Ramos, Thaís Lorenna Souza Sales, Polianna Delfino-Pereira, Karina Paula Medeiros Prado Martins, Andresa Fontoura Garbini, Angélica Gomides Dos Reis Gomes, Bruno Porto Pessoa, Carolina Cunha Matos and 24 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in BMC pregnancy and childbirth, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 19 institutions in 2 countries.

Zilma Silveira Nogueira ReisDepartment of Gynecology and Obstetrics, University Hospital. Universidade Federal de Minas Gerais, Av. Professor Alfredo Balena, 190, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0001-6374-9295
Magda Carvalho PiresDepartment of Statistics, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0003-3312-4002
Lucas Emanuel Ferreira RamosDepartment of Statistics, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0001-7844-0581
Thaís Lorenna Souza SalesUniversidade Federal de São João del-Rei, R. Sebastião Gonçalves Coelho, 400, Chanadour, Divinópolis, MG, 35501-296, Brazil. thaislorennass30@yahoo.com.br.ORCID http://orcid.org/0000-0002-1571-3850
Polianna Delfino-PereiraDepartment of Internal Medicine, Medical School, Universidade Federal de Minas Gerais, Av. Professor Alfredo Balena, 190, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0003-2406-6576
Karina Paula Medeiros Prado MartinsUniversity Hospital, Universidade Federal de Minas Gerais, Av. Professor Alfredo Balena, 190, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0002-8313-7429
Andresa Fontoura GarbiniHospital Nossa Senhora da Conceição and Hospital Cristo Redentor, Av. Francisco Trein, 326, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0002-3467-2150
Angélica Gomides Dos Reis GomesHospitais da Rede Mater Dei, Av. do Contorno, Belo Horizonte, 9000, Brazil.ORCID https://orcid.org/6536-4433-4015-0462
Bruno Porto PessoaHospital Júlia Kubitschek, R. Dr. Cristiano Rezende, Belo Horizonte, 2745, Brazil.ORCID https://orcid.org/0000-0002-4212-519X
Carolina Cunha MatosFaculdade de Ciências Médicas de Minas Gerais, Alameda Ezequiel Dias, 275, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0002-1067-6720
Christiane Corrêa Rodrigues CiminiHospital Santa Rosália, R. Dr. Onófre, 575, Teófilo Otoni, Brazil.ORCID https://orcid.org/0000-0002-1973-1343
Claudete RempelHospital Bruno Born, Av. Benjamin Constant, 881, Lajeado, Brazil.ORCID https://orcid.org/0000-0001-8573-0237
Daniela PonceBotucatu Medical School, Universidade Estadual Paulista "Júlio de Mesquita Filho" and Hospital das Clínicas da Faculdade de Medicina de Botucatu, Av. Prof. Mário Rubens Guimarães Montenegro, s/n, Botucatu, Brazil.ORCID https://orcid.org/0000-0002-6178-6938
Felipe Ferraz Martins Graça AranhaHospital SOS Cardio, Rodovia, SC-401, 121, Florianópolis, Brazil.ORCID https://orcid.org/0000-0003-0429-7641
Fernando AnschauHospital Nossa Senhora da Conceição and Hospital Cristo Redentor, Av. Francisco Trein, 326, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0002-2657-5406
Gabriela Petry CrestaniHospital Mãe de Deus, R. José de Alencar, 286, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0002-4991-4941
Genna Maira Santos GrizendeHospital Santa Casa de Misericórdia de Belo Horizonte, Av. Francisco Sales, 1111, Belo Horizonte, Brazil.ORCID http://orcid.org/0000-0001-6891-1087
Gisele Alsina Nader BastosHospital Moinhos de Vento, R. Ramiro Barcelos, 910, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0001-9668-1434
Giulia Maria Dos Santos GoedertMedical School, Universidade Federal de Santa Maria, Av. Roraima, 1000, Santa Maria, Brazil.ORCID https://orcid.org/0000-0002-6672-0276
Luanna Silva Monteiro MenezesHospital Metropolitano Odilon Behrens, R. Formiga, 50, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0002-6621-3338
Marcelo CarneiroHospital Santa Cruz, R. Fernando Abott, 174, Santa Cruz do Sul, Brazil.ORCID https://orcid.org/0000-0003-3603-1987
Marcia Ffner TolfoFaculdade Integrada de Santa Maria, R. José do Patrocínio, 26, Santa Maria, Brazil.ORCID https://orcid.org/0000-0001-5906-3610
Maria Augusta Matos CorrêaMucuri Medical School, Universidade Federal dos Vales do Jequitinhonha e Mucuri, R. Cruzeiro, 01, Teófilo Otoni, Brazil.ORCID https://orcid.org/0000-0003-0061-4072
Mariani Maciel de AmorimUniversidade Luterana do Brasil, Av. Farroupilha, 8001, Canoas, Brazil.ORCID https://orcid.org/0000-0001-6213-159X
Milton Henriques Guimarães JúniorHospital Márcio Cunha, Av. Kiyoshi Tsunawaki, 41, Ipatinga, Brazil.ORCID https://orcid.org/0000-0002-2127-8015
Pamela Andrea Alves DurãesPontifícia Universidade Católica de Minas Gerais, R. do Rosário, 1081, Betim, Brazil.ORCID https://orcid.org/0000-0002-5320-8572
Patryk Marques da Silva RosaCentro Universitário de Belo Horizonte, Av. Professor Werneck, 1685, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0002-1370-9073
Petrônio José de Lima MartelliCentro de Ciências Médicas, Universidade Federal de Pernambuco, Hospital das Clínicas da Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, Recife, Brazil.ORCID https://orcid.org/0000-0001-6920-6435
Rafaela Santos Charão de AlmeidaHospital Nossa Senhora da Conceição and Hospital Cristo Redentor, Av. Francisco Trein, 326, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0002-2091-5772
Raphael Castro MartinsHospital Tacchini, R. Dr. José Mário Mônaco, 358, Bento Gonçalves, Brazil.ORCID https://orcid.org/0000-0003-2167-3645
Samuel Penchel AlvarengaUniversidade Federal de São João del-Rei, R. Sebastião Gonçalves Coelho, 400, Chanadour, Divinópolis, MG, 35501-296, Brazil.ORCID https://orcid.org/0000-0002-1889-3455
Eric BoersmaDepartment of Cardiology, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-2559-7128
Regina Amélia Lopes Pessoa de AguiarDepartment of Gynecology and Obstetrics, University Hospital. Universidade Federal de Minas Gerais, Av. Professor Alfredo Balena, 190, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0003-2470-3539
Milena Soriano MarcolinoDepartment of Internal Medicine, Medical School, Universidade Federal de Minas Gerais, Av. Professor Alfredo Balena, 190, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0003-4278-3771
Universidade Federal de Minas Gerais · BRHospital Nossa Senhora da Conceição · BRFederal University of São João del-Rei · BRUniversidade Federal dos Vales do Jequitinhonha e Mucuri · BRCentro Universitário de Belo Horizonte · BRFaculdade de Ciências Médicas de Minas Gerais · BRGrupo Santa Casa de Belo Horizonte · BRHospital das Clínicas da Universidade Federal de Pernambuco · BRHospital Mãe de Deus · BRHospital Moinhos de Vento · BRInstituto Benjamin Constant · BRLaboratório Bacchi · BRMater Dei Hospital · BRPontifícia Universidade Católica de Minas Gerais · BRRotterdam University of Applied Sciences · NLUniversidade de Santa Cruz do Sul · BRUniversidade Estadual Paulista (Unesp) · BRUniversidade Federal de Santa Maria · BRUniversidade Luterana do Brasil · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 147122/2021-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 305837/2021-4Conselho Nacional de Desenvolvimento Científico e Tecnológico 465518/2014-1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.507149/2020-00Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-00208-20
6 · The paper itself

Abstract

backgroundThe assessment of clinical prognosis of pregnant COVID-19 patients at hospital presentation is challenging, due to physiological adaptations during pregnancy. Our aim was to assess the performance of the ABC

methodsThis multicenter cohort included consecutive pregnant patients with COVID-19 admitted to the participating hospitals, from April/2020 to March/2022. Primary outcomes were in-hospital mortality and the composite outcome of mechanical ventilation support and in-hospital mortality. Secondary endpoints were pregnancy outcomes. The overall discrimination of the model was presented as the area under the receiver operating characteristic curve (AUROC). Overall performance was assessed using the Brier score.

resultsFrom 350 pregnant patients (median age 30 [interquartile range (25.2, 35.0)] years-old]), 11.1% had hypertensive disorders, 19.7% required mechanical ventilation support and 6.0% died. The AUROC for in-hospital mortality and for the composite outcome were 0.809 (95% IC: 0.641-0.944) and 0.704 (95% IC: 0.617-0.792), respectively, with good overall performance (Brier = 0.0384 and 0.1610, respectively). Calibration was good for the prediction of in-hospital mortality, but poor for the composite outcome. Women who died had a median age 4 years-old higher, higher frequency of hypertensive disorders (38.1% vs. 9.4%, p < 0.001) and obesity (28.6% vs. 10.6%, p = 0.025) than those who were discharged alive, and their newborns had lower birth weight (2000 vs. 2813, p = 0.001) and five-minute Apgar score (3.0 vs. 8.0, p < 0.001).

conclusionsThe ABC

Indexed as

COVID-19Hospital MortalityRespiration, ArtificialAdultBirth WeightBrazilFemaleHumansHypertension, Pregnancy-InducedInfant, NewbornPregnancyPrognosisRetrospective StudiesArtificial respirationClinical decision rulesCOVID-19MortalityPregnant womenPrognosis

Identifiers

PMID36627576
PMCPMC9830611
OpenAlexW4315491325

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