Evidence map›Paper›PMID 36627511›Full record

ArticleNature reviews. Neurology2023

Biomarker-based diagnosis of preclinical Alzheimer disease: time for the clinic?

Marwan N Sabbagh, Boris DeCourt

Abstract readComment
In one paragraph

Article in Nature reviews. Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Marwan N SabbaghAlzheimer's Clinical and Translational Research Lab, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. neuropub@barrowneuro.org.
Boris DeCourtTranslational Neurodegenerative Research Lab, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.

Funding

MCLENA-1: A Clinical Trial for the Assessment of Lenalidomide in Amnestic MCI PatientsR01AG059008 · NIA · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI DECOURT, BORIS, SABBAGH, MARWAN NOEL · 2018 to 2023
$3.6M
Repurposing Siponimod for Alzheimer's DiseaseR01AG073212 · NIA · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI Boris Decourt, MARWAN Noel SABBAGH · 2021 to 2026
$2.8M
Pre-clinical testing of lenalidomide as pleiotropic therapeutics of Alzheimer's diseaseK01AG047279 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI DECOURT, BORIS · 2015 to 2019
$534k
NIA NIH HHS K01 AG047279NIA NIH HHS R01 AG059008NIA NIH HHS R01 AG073212
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBiomarkersHumansAmyloid beta-PeptidesBiomarkers

Identifiers

PMID36627511
PMCPMC10342128

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.